The RNA Exosome Adaptor ZFC3H1 Functionally Competes with Nuclear Export Activity to Retain Target Transcripts
Sign Up to like & getrecommendations! Published in 2018 at "Cell Reports"
DOI: 10.1016/j.celrep.2018.04.061
Abstract: Summary Mammalian genomes are promiscuously transcribed, yielding protein-coding and non-coding products. Many transcripts are short lived due to their nuclear degradation by the ribonucleolytic RNA exosome. Here, we show that abolished nuclear exosome function causes… read more here.
Keywords: export; export activity; rna exosome; nuclear export ... See more keywords
PD-L1 (B7-H1) Competes with the RNA Exosome to Regulate the DNA Damage Response and Can Be Targeted to Sensitize to Radiation or Chemotherapy.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.04.005
Abstract: Programmed death ligand 1 (PD-L1, also called B7-H1) is an immune checkpoint protein that inhibits immune function through its binding of the programmed cell death protein 1 (PD-1) receptor. Clinically approved antibodies block extracellular PD-1… read more here.
Keywords: chemotherapy; dna damage; damage response; dna ... See more keywords
RST1 and RIPR connect the cytosolic RNA exosome to the Ski complex in Arabidopsis
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-11807-4
Abstract: The RNA exosome is a key 3’−5’ exoribonuclease with an evolutionarily conserved structure and function. Its cytosolic functions require the co-factors SKI7 and the Ski complex. Here we demonstrate by co-purification experiments that the ARM-repeat… read more here.
Keywords: rna exosome; ski complex; rst1 ripr; exosome ski ... See more keywords
The splicing factor SRSF3 is functionally connected to the nuclear RNA exosome for intronless mRNA decay
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-31078-1
Abstract: The RNA exosome fulfills important functions in the processing and degradation of numerous RNAs species. However, the mechanisms of recruitment to its various nuclear substrates are poorly understood. Using Epstein-Barr virus mRNAs as a model,… read more here.
Keywords: rna exosome; nuclear rna; splicing factor; mrna decay ... See more keywords
Harnessing endogenous transcription factors directly by small molecules for chemically induced pluripotency inception.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2215155120
Abstract: Chemistry-alone approach has recently been applied for incepting pluripotency in somatic cells, representing a breakthrough in biology. However, chemical reprogramming is hampered by low efficiency, and the underlying molecular mechanisms remain unclear. Particularly, chemical compounds… read more here.
Keywords: transcription; pluripotency; rna exosome; small molecules ... See more keywords
The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad140
Abstract: Abstract The RNA exosome is an essential 3′ to 5′ exoribonuclease complex that mediates degradation, processing and quality control of virtually all eukaryotic RNAs. The nucleolar RNA exosome, consisting of a nine-subunit core and a… read more here.
Keywords: specific protease; protease usp36; ubiquitin specific; rna exosome ... See more keywords
The RNA exosome contributes to gene expression regulation during stem cell differentiation
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky817
Abstract: Abstract Gene expression programs change during cellular transitions. It is well established that a network of transcription factors and chromatin modifiers regulate RNA levels during embryonic stem cell (ESC) differentiation, but the full impact of… read more here.
Keywords: rna exosome; gene expression; expression; differentiation ... See more keywords
Structure of the nuclear exosome captured on a maturing preribosome
Sign Up to like & getrecommendations! Published in 2018 at "Science"
DOI: 10.1126/science.aar5428
Abstract: The RNA exosome captured in action The RNA exosome, a major RNA degradation machine, processes ribosomal RNA (rRNA) precursors and is directly coupled to the protein synthesis machine, the ribosome. Using cryo–electron microscopy, Schuller et… read more here.
Keywords: microscopy; rna exosome; exosome captured; exosome ... See more keywords
An RNA exosome subunit mediates cell-to-cell trafficking of a homeobox mRNA via plasmodesmata
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.abm0840
Abstract: Description mRNA migration through plasmodesmata In plants, certain transcription factors are produced in one cell but transported, sometimes as messenger RNA (mRNA), through plasmodesmata, channels between neighboring plant cells, where they act. This system helps… read more here.
Keywords: cell; mrna; rna exosome; subunit ... See more keywords
A Budding Yeast Model for Human Disease Mutations in the EXOSC2 Cap Subunit of the RNA Exosome.
Sign Up to like & getrecommendations! Published in 2021 at "RNA"
DOI: 10.1261/rna.078618.120
Abstract: RNA exosomopathies, a growing family of diseases, are linked to missense mutations in genes encoding structural subunits of the evolutionarily conserved, 10-subunit exoribonuclease complex, the RNA exosome. This complex consists of a 3-subunit cap, a… read more here.
Keywords: budding yeast; cap subunit; rna exosome; function ... See more keywords
RNA exosome mutations in pontocerebellar hypoplasia alter ribosome biogenesis and p53 levels
Sign Up to like & getrecommendations! Published in 2020 at "Life Science Alliance"
DOI: 10.26508/lsa.202000678
Abstract: The work highlights the link between dysfunction of the RNA exosome, ribosome biogenesis, p53-dependent signalling, and apoptosis. Pontocerebellar hypoplasia caused by mutations of the exosome subunits could be classified as a ribosomopathy. The RNA exosome… read more here.
Keywords: rna exosome; biogenesis p53; p53; pontocerebellar hypoplasia ... See more keywords