Colorimetric detection of RNA fragments based on associated toehold-mediated reaction and gold nanoparticles.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc02389j
Abstract: Herein we report a reverse transcription-free, label-free and enzyme-free colorimetric method for RNA nucleic acid fragments detection. The method can conveniently determine the presence of dual gene targets and distinguish single nucleotide polymorphism by visual… read more here.
Keywords: detection rna; rna; rna fragments; detection ... See more keywords
Processing by RNase 1 forms tRNA halves and distinct Y RNA fragments in the extracellular environment
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa526
Abstract: Abstract Extracellular RNAs participate in intercellular communication, and are being studied as promising minimally invasive diagnostic markers. Several studies in recent years showed that tRNA halves and distinct Y RNA fragments are abundant in the… read more here.
Keywords: trna halves; halves distinct; distinct rna; rnase ... See more keywords
Enzymatic Conjugation of Modified RNA Fragments by Ancestral RNA Ligase AncT4_2
Sign Up to like & getrecommendations! Published in 2022 at "Applied and Environmental Microbiology"
DOI: 10.1128/aem.01679-22
Abstract: RNA therapeutics is one of the next-generation medicines for treating various diseases. Our designed ancestral RNA ligase AncT4_2 exhibited excellent enzymatic properties, such as high thermal stability, productivity, specific activity, and broad substrate selectivity compared… read more here.
Keywords: modified rna; rna; anct4; rna fragments ... See more keywords
Distinct SARS-CoV-2 RNA fragments activate Toll-like receptors 7 and 8 and induce cytokine release from human macrophages and microglia
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1066456
Abstract: Introduction The pandemic coronavirus disease 19 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is marked by thromboembolic events and an inflammatory response throughout the body, including the brain Methods Employing… read more here.
Keywords: toll like; cov rna; rna fragments; human macrophages ... See more keywords
Current Status of Regulatory Non-Coding RNAs Research in the Tritryp
Sign Up to like & getrecommendations! Published in 2022 at "Non-Coding RNA"
DOI: 10.3390/ncrna8040054
Abstract: Trypanosomatids are protozoan parasites that cause devastating vector-borne human diseases. Gene expression regulation of these organisms depends on post-transcriptional control in responding to diverse environments while going through multiple developmental stages of their complex life… read more here.
Keywords: coding rnas; rna; rna fragments; small rna ... See more keywords