Mutational analysis of the functional motifs of the DEAD-box RNA helicase Me31B/DDX6 in Drosophila germline development.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS letters"
DOI: 10.1002/1873-3468.14668
Abstract: Me31B/DDX6 is a DEAD-box family RNA helicase playing roles in post-transcriptional RNA regulation in different cell types and species. Despite the known motifs/domains of Me31B, the in vivo functions of the motifs remain unclear. Here,… read more here.
Keywords: me31b ddx6; rna helicase; germline; dead box ... See more keywords
Peanut RNA Helicase AhRH47 Sustains Protein Synthesis Under Stress and Improves Stress Adaptation in Arabidopsis
Sign Up to like & getrecommendations! Published in 2017 at "Plant Molecular Biology Reporter"
DOI: 10.1007/s11105-017-1056-9
Abstract: Stress responsive RNA helicases are involved in translation initiation sustain protein synthesis. In this study, a stress responsive DEAD box RNA helicase, AhRH47 from peanut cDNA library was identified and characterised during stress. In silico… read more here.
Keywords: stress; rna helicase; protein synthesis; ahrh47 ... See more keywords
SARS-Coronavirus-2 Nsp13 Possesses NTPase and RNA Helicase Activities That Can Be Inhibited by Bismuth Salts
Sign Up to like & getrecommendations! Published in 2020 at "Virologica Sinica"
DOI: 10.1007/s12250-020-00242-1
Abstract: The ongoing outbreak of Coronavirus Disease 2019 (COVID-19) has become a global public health emergency. SARS-coronavirus-2 (SARS-CoV-2), the causative pathogen of COVID-19, is a positive-sense single-stranded RNA virus belonging to the family Coronaviridae . For… read more here.
Keywords: rna helicase; ntpase rna; sars coronavirus; sars cov ... See more keywords
Knockdown of DEAD-box RNA helicase DDX5 selectively attenuates serine 311 phosphorylation of NF-κB p65 subunit and expression level of anti-apoptotic factor Bcl-2.
Sign Up to like & getrecommendations! Published in 2019 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2019.109428
Abstract: NF-κB plays a key role in the transcriptional regulation of genes involved in immunity, inflammation, cell proliferation, and oncogenesis. The NF-κB activation process includes nuclear translocation, followed by association with basal transcription machinery. These steps… read more here.
Keywords: expression level; rna helicase; dead box; phosphorylation p65 ... See more keywords
Evaluation of antileishmanial potential of computationally screened compounds targeting DEAD-box RNA helicase of Leishmania donovani.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.10.053
Abstract: Visceral leishmaniasis (VL) is one of the most devastating diseases of the tropical region caused by protozoan parasite Leishmania donovani. So far, there is no effective drug and vaccine available against this fatal disease. The… read more here.
Keywords: rna helicase; rna; dead box; donovani ... See more keywords
RNA Helicase DDX1 Converts RNA G-Quadruplex Structures into R-Loops to Promote IgH Class Switch Recombination
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cell"
DOI: 10.1016/j.molcel.2018.04.001
Abstract: Summary Class switch recombination (CSR) at the immunoglobulin heavy-chain (IgH) locus is associated with the formation of R-loop structures over switch (S) regions. While these often occur co-transcriptionally between nascent RNA and template DNA, we… read more here.
Keywords: helicase ddx1; rna helicase; switch; class switch ... See more keywords
Closing in on ATPase Activity by an RNA Helicase.
Sign Up to like & getrecommendations! Published in 2020 at "Structure"
DOI: 10.1016/j.str.2020.01.007
Abstract: In this issue of Structure, Absmeier et al. (2020) describe the molecular mechanisms employed by an RNA helicase to prevent premature ATP hydrolysis upon nucleotide binding. read more here.
Keywords: closing atpase; rna helicase; activity rna; helicase ... See more keywords
Substrate Determinants for Unwinding Activity of the DExH/D-Box Protein RNA Helicase A.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b01025
Abstract: RNA helicase A (RHA) as a member of the DExH/D-box subgroup of helicase superfamily II is involved in virtually all aspects of RNA metabolism. It exhibits robust RNA helicase activity in vitro. However, little is… read more here.
Keywords: substrate determinants; rna helicase; dexh box; rha ... See more keywords
USP42 enhances homologous recombination repair by promoting R-loop resolution with a DNA–RNA helicase DHX9
Sign Up to like & getrecommendations! Published in 2020 at "Oncogenesis"
DOI: 10.1038/s41389-020-00244-4
Abstract: The nucleus of mammalian cells is compartmentalized by nuclear bodies such as nuclear speckles, however, involvement of nuclear bodies, especially nuclear speckles, in DNA repair has not been actively investigated. Here, our focused screen for… read more here.
Keywords: nuclear speckles; dsb; homologous recombination; rna helicase ... See more keywords
m6A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-13317-9
Abstract: Dynamic mRNA modification in the form of N 6 -methyladenosine (m6A) adds considerable richness and sophistication to gene regulation. The m6A mark is asymmetrically distributed along mature mRNAs, with approximately 35% of m6A residues located… read more here.
Keywords: rna helicase; cds m6a; translation; m6a reader ... See more keywords
The RNA Helicase Ski2 in the Fungal Pathogen Cryptococcus neoformans Highlights Key Roles in Azoles Resistance and Stress Tolerance.
Sign Up to like & getrecommendations! Published in 2022 at "Medical mycology"
DOI: 10.1093/mmy/myac083
Abstract: The yeast SKI (superkiller) complex was originally identified from cells that were infected by the M 'killer' virus. Ski2, as the core of the SKI complex, is a cytoplasmic cofactor and regulator of RNA-degrading exosome.… read more here.
Keywords: rna helicase; ski2; helicase ski2; resistance ... See more keywords