RNA helicases are hubs that orchestrate exosome-dependent 3'-5' decay.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2020.09.010
Abstract: The RNA exosome is a conserved complex of proteins that mediates 3'-5' RNA processing and decay. Its functions range from processing of non-coding RNAs such as ribosomal RNAs and decay of aberrant transcripts in the… read more here.
Keywords: decay; exosome; rna helicases; dependent decay ... See more keywords
RNA helicases regulate RNA condensates
Sign Up to like & getrecommendations! Published in 2020 at "Cell Research"
DOI: 10.1038/s41422-020-0296-7
Abstract: Stress granules are cytoplasmic membraneless RNA condensates for storing non-translating mRNAs, which are induced in response to various forms of stress. In a recent issue of Cell, Tauber et al. show that RNA helicases, particularly… read more here.
Keywords: rna rna; rna; rna interactions; formation ... See more keywords
DEAD-box RNA helicases Dbp2, Ded1 and Mss116 bind to G-quadruplex nucleic acids and destabilize G-quadruplex RNA.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c8cc10091h
Abstract: We identified 29 G-quadruplex binding proteins by affinity purification and quantitative LC-MS/MS. We demonstrated that the DEAD-box RNA helicases Dbp2, Ded1 and Mss116 preferentially bind to G-quadruplex nucleic acids in vitro and destabilize RNA quadruplexes,… read more here.
Keywords: rna; dead box; helicases dbp2; rna helicases ... See more keywords
RNA folding and functions of RNA helicases in ribosome biogenesis
Sign Up to like & getrecommendations! Published in 2022 at "RNA Biology"
DOI: 10.1080/15476286.2022.2079890
Abstract: ABSTRACT Eukaryotic ribosome biogenesis involves the synthesis of ribosomal RNA (rRNA) and its stepwise folding into the unique structure present in mature ribosomes. rRNA folding starts already co-transcriptionally in the nucleolus and continues when pre-ribosomal… read more here.
Keywords: rna folding; ribosome biogenesis; rna; rna helicases ... See more keywords
Functions and mechanisms of RNA helicases in plants.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of experimental botany"
DOI: 10.1093/jxb/erac462
Abstract: RNA helicases (RHs) are a family of ubiquitous enzymes that alter RNA structures and remodel ribonucleoprotein complexes (RNPs) using the energy typically through hydrolysis of adenosine 5'-triphosphate (ATP). RHs are involved in various aspects of… read more here.
Keywords: functions mechanisms; mechanisms rna; rna helicases; helicases plants ... See more keywords
An RNAi screen of RNA helicases identifies eIF4A3 as a regulator of embryonic stem cell identity
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1084
Abstract: Abstract RNA helicases are involved in multiple steps of RNA metabolism to direct their roles in gene expression, yet their functions in pluripotency control remain largely unexplored. Starting from an RNA interference (RNAi) screen of… read more here.
Keywords: cell; rnai screen; rna helicases; pluripotency ... See more keywords
Identification of RNA helicases with unwinding activity on angiogenin-processed tRNAs
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad033
Abstract: Abstract Stress-induced tRNA fragmentation upon environmental insult is a conserved cellular process catalysed by endonucleolytic activities targeting mature tRNAs. The resulting tRNA-derived small RNAs (tsRNAs) have been implicated in various biological processes that impact cell-to-cell… read more here.
Keywords: identification rna; identification; helicases unwinding; stress induced ... See more keywords
Molecular functions of RNA helicases during ribosomal subunit assembly
Sign Up to like & getrecommendations! Published in 2023 at "Biological Chemistry"
DOI: 10.1515/hsz-2023-0135
Abstract: Abstract During their biogenesis, the ribosomal subunits undergo numerous structural and compositional changes to achieve their final architecture. RNA helicases are a key driving force of such remodelling events but deciphering their particular functions has… read more here.
Keywords: rna helicases; molecular functions; ribosomal subunit; functions rna ... See more keywords
RNA Helicases in Microsatellite Repeat Expansion Disorders and Neurodegeneration
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.886563
Abstract: Short repeated sequences of 3−6 nucleotides are causing a growing number of over 50 microsatellite expansion disorders, which mainly present with neurodegenerative features. Although considered rare diseases in relation to the relatively low number of… read more here.
Keywords: rna helicases; microsatellite repeat; repeat expansion; expansion disorders ... See more keywords
The DEAD-Box RNA Helicases of Bacillus subtilis as a Model to Evaluate Genetic Compensation Among Duplicate Genes
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2018.02261
Abstract: The presence of duplicated genes in organisms is well documented. There is increasing interest in understanding how these genes subfunctionalize and whether functional overlap can explain the fact that some of these genes are dispensable.… read more here.
Keywords: rna; dead box; rna helicases; bacillus subtilis ... See more keywords
DEAD-Box RNA Helicases and Genome Stability
Sign Up to like & getrecommendations! Published in 2021 at "Genes"
DOI: 10.3390/genes12101471
Abstract: DEAD-box RNA helicases are important regulators of RNA metabolism and have been implicated in the development of cancer. Interestingly, these helicases constitute a major recurring family of RNA-binding proteins important for protecting the genome. Current… read more here.
Keywords: rna; dead box; rna helicases; stability ... See more keywords