Dynamics of Various Phospholipase C-B Complexes
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.526
Abstract: Phospholipase C-β (PLCβ) is activated by G protein signals from different hormones and neurotransmitters on the plasma membrane, to mediate increases in intracellular calcium. Surprisingly, we find that PLCβ also localizes to the cytoplasm where… read more here.
Keywords: induced silencing; dynamics various; phospholipase; various phospholipase ... See more keywords
A brain-targeting lipidated peptide for neutralizing RNA-mediated toxicity in Polyglutamine Diseases
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-11695-y
Abstract: Polyglutamine (PolyQ) diseases are progressive neurodegenerative disorders caused by both protein- and RNA-mediated toxicities. We previously showed that a peptidyl inhibitor, P3, which binds directly to expanded CAG RNA can inhibit RNA-induced nucleolar stress and… read more here.
Keywords: rna mediated; peptide; rna; polyglutamine ... See more keywords
Rational optimization of siRNA to ensure strand bias in the interaction with the RNA-induced silencing complex.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc01143g
Abstract: To ensure specificity of small interfering RNAs (siRNAs), the antisense strand must be selected by the RNA-induced silencing complex (RISC). We have previously demonstrated that a 5'-morpholino-modified nucleotide at the 5'-end of the sense strand… read more here.
Keywords: silencing complex; strand; induced silencing; rna induced ... See more keywords
In Arabidopsis thaliana, RNA-Induced Silencing Complex-Loading of MicroRNAs Plays a Minor Regulatory Role During Photomorphogenesis Except for miR163
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.854869
Abstract: The shift of dark-grown seedlings to the light leads to substantial reprogramming of gene expression, which results in dramatic developmental changes (referred to as de-etiolation or photomorphogenesis). MicroRNAs (miRNAs) regulate most steps of plant development,… read more here.
Keywords: induced silencing; role; photomorphogenesis; rna induced ... See more keywords
Small interfering RNA-induced silencing of galectin-3 inhibits the malignant phenotypes of osteosarcoma in vitro
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2021.12309
Abstract: Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that certain of the Transwell cell migration assay data shown in Figs. 4B and 5B were strikingly similar to… read more here.
Keywords: medicine reports; medicine; small interfering; molecular medicine ... See more keywords