Trisubstituted Pyrrolinones as Small-Molecule Inhibitors Disrupting the Protein–RNA Interaction of LIN28 and Let-7
Sign Up to like & getrecommendations! Published in 2021 at "ACS Medicinal Chemistry Letters"
DOI: 10.1021/acsmedchemlett.0c00546
Abstract: Modulation of protein–RNA interaction (PRI) using small molecules is a promising strategy to develop therapeutics. LIN28 is an RNA-binding protein that blocks the maturation of the tumor suppressor let-7 microRNAs. Herein, we performed a fluorescence… read more here.
Keywords: protein; rna interaction; lin28; interaction ... See more keywords
Global pairwise RNA interaction landscapes reveal core features of protein recognition
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-04729-0
Abstract: RNA–protein interactions permeate biology. Transcription, translation, and splicing all hinge on the recognition of structured RNA elements by RNA-binding proteins. Models of RNA–protein interactions are generally limited to short linear motifs and structures because of… read more here.
Keywords: global pairwise; rna interaction; rna; recognition ... See more keywords
Protein-RNA interaction dynamics reveal key regulators of oncogenic KRAS-driven cancers
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-78333-2
Abstract: KRAS is one of the most frequently mutated oncogenes across various cancers. Oncogenic KRAS mutations rewire cellular signaling, leading to significant alterations in gene expression. RNA-binding proteins (RBPs) play a pivotal role in gene expression… read more here.
Keywords: oncogenic kras; interaction dynamics; rna interaction; kras mutant ... See more keywords
PRIME-3D2D is a 3D2D model to predict binding sites of protein–RNA interaction
Sign Up to like & getrecommendations! Published in 2020 at "Communications Biology"
DOI: 10.1038/s42003-020-1114-y
Abstract: Protein-RNA interaction participates in many biological processes. So, studying protein–RNA interaction can help us to understand the function of protein and RNA. Although the protein–RNA 3D3D model, like PRIME, was useful in building 3D structural complexes,… read more here.
Keywords: rna interaction; prime 3d2d; predict binding; binding sites ... See more keywords
CheRRI—Accurate classification of the biological relevance of putative RNA–RNA interaction sites
Sign Up to like & getrecommendations! Published in 2024 at "GigaScience"
DOI: 10.1093/gigascience/giae022
Abstract: Abstract Background RNA–RNA interactions are key to a wide range of cellular functions. The detection of potential interactions helps to understand the underlying processes. However, potential interactions identified via in silico or experimental high-throughput methods… read more here.
Keywords: rna interaction; rna rna; rna; biological relevance ... See more keywords
Ancestry of RNA/RNA interaction regions within segmented ribosomes.
Sign Up to like & getrecommendations! Published in 2023 at "RNA"
DOI: 10.1261/rna.079654.123
Abstract: The ribosome is the universally conserved ribozyme that translates DNA coded instructions into proteins with the assistance of other RNA molecules including transfer and messenger RNAs. Of particular interest is the segmentation phenomena, which is… read more here.
Keywords: segmented ribosomes; rna; interaction regions; rna interaction ... See more keywords