Tips for Successful lncRNA Knockdown Using Gapmers.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0771-8_9
Abstract: Long noncoding RNAs (lncRNAs) are a recently discovered class of RNA that have diverse intracellular regulatory and structural roles. Because of their wide assortment of functions, lncRNAs can have varied distributions in the nucleus and/or… read more here.
Keywords: tips successful; lncrna knockdown; successful lncrna; using gapmers ... See more keywords
Allele-Specific RNA Knockdown with a Biologically Stable and Catalytically Efficient XNAzyme.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c11353
Abstract: Therapeutic targeting of allele-specific single nucleotide mutations in RNA is a major challenge in biology and medicine. Herein, we describe the utility of the XNAzyme X10-23 to knock down allele-specific mRNA sequences in cells. We… read more here.
Keywords: specific rna; xnazyme; knockdown biologically; rna knockdown ... See more keywords
Dsi-RNA knockdown of genes regulated by Foxo reduces glycogen and lipid accumulations in diapausing Culex pipiens
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DOI: 10.1038/s41598-020-74292-6
Abstract: Culex pipiens is a major carrier of the West Nile Virus, the leading cause of mosquito-borne disease in the continental United States. Cx. pipiens survive overwinter through diapause which is an important survival strategy that… read more here.
Keywords: culex pipiens; knockdown genes; rna knockdown; glycogen lipid ... See more keywords