RNA dynamics revealed by metabolic RNA labeling and biochemical nucleoside conversions
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DOI: 10.1038/nmeth.4608
Abstract: The combination of metabolic RNA labeling with biochemical nucleoside conversion now adds a broadly applicable temporal dimension to RNA sequencing. read more here.
Keywords: rna dynamics; metabolic rna; biochemical nucleoside; rna ... See more keywords
On the optimal design of metabolic RNA labeling experiments
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DOI: 10.1371/journal.pcbi.1007252
Abstract: Massively parallel RNA sequencing (RNA-seq) in combination with metabolic labeling has become the de facto standard approach to study alterations in RNA transcription, processing or decay. Regardless of advances in the experimental protocols and techniques,… read more here.
Keywords: metabolic rna; optimal design; rna labeling; design metabolic ... See more keywords
Selective RNA Labeling by RNA-Compatible Type II Restriction Endonuclease and RNA-Extending DNA Polymerase
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DOI: 10.3390/life12101674
Abstract: RNAs not only offer valuable information regarding our bodies but also regulate cellular functions, allowing for their specific manipulations to be extensively explored for many different biological and clinical applications. In particular, rather than temporary… read more here.
Keywords: dna polymerase; restriction; rna; rna labeling ... See more keywords