Efficient computation of co-transcriptional RNA-ligand interaction dynamics.
Sign Up to like & getrecommendations! Published in 2018 at "Methods"
DOI: 10.1016/j.ymeth.2018.04.036
Abstract: Riboswitches form an abundant class of cis-regulatory RNA elements that mediate gene expression by binding a small metabolite. For synthetic biology applications, they are becoming cheap and accessible systems for selectively triggering transcription or translation… read more here.
Keywords: ligand interaction; rna ligand; interaction dynamics; transcriptional rna ... See more keywords
RNA-Ligand Interactions Quantified by Surface Plasmon Resonance with Reference Subtraction.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00177
Abstract: Structured RNAs bind ligands and are attractive targets for small-molecule drugs. A wide variety of analytical methods have been used to characterize RNA-ligand interactions, but our experience is that most have significant limitations in terms… read more here.
Keywords: surface plasmon; subtraction; reference; ligand ... See more keywords
Enhancement of RNA/Ligand Association Kinetics via an Electrostatic Anchor
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00231
Abstract: The diverse biological processes mediated by RNA rest upon its recognition of various ligands, including small molecules and nucleic acids. Nevertheless, a recent literature survey suggests that RNA molecular recognition of these ligands is slow,… read more here.
Keywords: ligand association; via electrostatic; association; rna ligand ... See more keywords
A minimal RNA ligand for potent RIG-I activation in living mice
Sign Up to like & getrecommendations! Published in 2018 at "Science Advances"
DOI: 10.1126/sciadv.1701854
Abstract: Short stem-loop RNAs activate RIG-I in mice, activating the innate immune system via specific patterns of gene expression. We have developed highly potent synthetic activators of the vertebrate immune system that specifically target the RIG-I… read more here.
Keywords: rig activation; rig; immune system; rna ligand ... See more keywords
Tractable RNA–ligand interaction kinetics
Sign Up to like & getrecommendations! Published in 2017 at "BMC Bioinformatics"
DOI: 10.1186/s12859-017-1823-5
Abstract: BackgroundThe binding of small ligands to RNA elements can cause substantial changes in the RNA structure. This constitutes an important, fast-acting mechanism of ligand-controlled transcriptional and translational gene regulation implemented by a wide variety of… read more here.
Keywords: ligand interaction; ligand; rna ligand; analysis ... See more keywords
RNALigands: a database and web server for RNA - ligand interactions.
Sign Up to like & getrecommendations! Published in 2021 at "RNA"
DOI: 10.1261/rna.078889.121
Abstract: MOTIVATION RNA molecules can fold into complex and stable 3-D structures, allowing them to carry out important genetic, structural, and regulatory roles inside the cell. These complex structures often contain 3-D pockets made up of… read more here.
Keywords: server; secondary structural; rna ligand; structural motifs ... See more keywords