nc‐RNA‐mediated high expression of CDK6 correlates with poor prognosis and immune infiltration in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5260
Abstract: Emerging evidence manifests that cyclin‐dependent kinase 6 (CDK6) plays an essential part in the initiation and progression of several types of human cancer, and its descending expression is correlated with an adverse prognosis. However, the… read more here.
Keywords: prognosis; pancreatic cancer; rna mediated; expression ... See more keywords
Molecular dynamics simulations of early steps in RNA‐mediated conversion of prions
Sign Up to like & getrecommendations! Published in 2017 at "Protein Science"
DOI: 10.1002/pro.3178
Abstract: The rate‐limiting step in prion diseases is the initial transition of a prion protein from its native form into a mis‐folded state in which the protein not only forms cell‐toxic aggregates but also becomes infectious.… read more here.
Keywords: rna mediated; molecular dynamics; simulations early; polyadenosine rna ... See more keywords
Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.07.058
Abstract: In the cytoplasm, small RNAs can control mammalian translation by regulating the stability of mRNA. In the nucleus, small RNAs can also control transcription and splicing. The mechanisms for RNA-mediated nuclear regulation are not understood… read more here.
Keywords: transcription; rna mediated; control transcription; gw182 paralogs ... See more keywords
RNA-Mediated Dimerization of the Human Deoxycytidine Deaminase APOBEC3H Influences Enzyme Activity and Interaction with Nucleic Acids.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2018.11.006
Abstract: Human APOBEC3H is a single-stranded (ss)DNA deoxycytidine deaminase that inhibits replication of retroelements and HIV-1 in CD4+ T cells. When aberrantly expressed in lung or breast tissue, APOBEC3H can contribute to cancer mutagenesis. These different… read more here.
Keywords: mediated dimerization; rna mediated; rna; deoxycytidine deaminase ... See more keywords
A brain-targeting lipidated peptide for neutralizing RNA-mediated toxicity in Polyglutamine Diseases
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-11695-y
Abstract: Polyglutamine (PolyQ) diseases are progressive neurodegenerative disorders caused by both protein- and RNA-mediated toxicities. We previously showed that a peptidyl inhibitor, P3, which binds directly to expanded CAG RNA can inhibit RNA-induced nucleolar stress and… read more here.
Keywords: rna mediated; peptide; rna; polyglutamine ... See more keywords
A novel RNA-mediated mechanism causing down-regulation of insulating promoter interactions in human embryonic stem cells
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-02373-1
Abstract: The genome-wide promoter interactome is primarily maintained and regulated by architectural proteins such as CTCF and cohesin. However, some studies suggest a role for non-coding RNAs (ncRNAs) in this process. We aimed to characterise the… read more here.
Keywords: expression; rna mediated; insulating promoter; promoter ... See more keywords
Small RNA-Mediated De Novo Silencing of Ac/Ds Transposons Is Initiated by Alternative Transposition in Maize.
Sign Up to like & getrecommendations! Published in 2020 at "Genetics"
DOI: 10.1534/genetics.120.303264
Abstract: Transposable elements (TEs) are a ubiquitous feature of plant genomes. Because of the threat they pose to genome integrity, most TEs are epigenetically silenced. However, even closely related plant species... Although transposable elements (TEs) comprise… read more here.
Keywords: small rna; rna mediated; transposition; alternative transposition ... See more keywords