Immune dysregulation and RNA N6‐methyladenosine modification in sepsis
Sign Up to like & getrecommendations! Published in 2022 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1764
Abstract: Sepsis is defined as life‐threatening organ dysfunction caused by the host immune dysregulation to infection. It is a highly heterogeneous syndrome with complex pathophysiological mechanisms. The host immune response to sepsis can be divided into… read more here.
Keywords: sepsis; modification; rna methyladenosine; modification sepsis ... See more keywords
RNA N 6-Methyladenosine Modification in Normal and Malignant Hematopoiesis.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-7342-8_4
Abstract: As the most abundant internal modification in eukaryotic messenger RNAs (mRNAs), N 6-methyladenosine (m6A) modification has been shown recently to posttranscriptionally regulate expression of thousands of messenger RNA (mRNA) transcripts in each mammalian cell type… read more here.
Keywords: hematopoiesis; m6a modification; rna methyladenosine; methyladenosine modification ... See more keywords
Functions of RNA N6-methyladenosine modification in cancer progression
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology Reports"
DOI: 10.1007/s11033-019-04655-4
Abstract: N6-methyladenosine (m6A) serves as a major RNA methylation modification and impacts the initiation and progression of various human cancers through diverse mechanisms. It has been reported that m6A RNA methylation is involved in different physiological… read more here.
Keywords: rna methyladenosine; methyladenosine modification; functions rna; progression ... See more keywords
Role of identified RNA N6-methyladenosine methylation in liver.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2019.05.005
Abstract: N6-Methyladenosine (m6A) is the most abundant and important internal modification site of RNA methylation in viruses and eukaryotic. m6A RNA methylation plays key roles in the regulation of post-transcriptional gene expression, including messenger RNA (mRNA),… read more here.
Keywords: identified rna; methylation; role identified; rna methyladenosine ... See more keywords
RNA N-6-methyladenosine enzymes and resistance of cancer cells to chemotherapy and radiotherapy.
Sign Up to like & getrecommendations! Published in 2020 at "Epigenomics"
DOI: 10.2217/epi-2019-0358
Abstract: Aim: As one of the early adaptive mechanisms by which cells respond to environmental changes, RNA modification appears to be a very promising target for cancer treatment. Results: RNA modifications are currently a hot topic… read more here.
Keywords: cancer cells; resistance; rna methyladenosine; resistance cancer ... See more keywords
RNA N1-methyladenosine regulator-mediated methylation modification patterns and heterogeneous signatures in glioma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.948630
Abstract: N1-methyladenosine (m1A) is ubiquitous in eukaryotic RNA and regulates mRNA translation. However, little is known about its regulatory role in glioma. Here, we identified 4 m1A modification-related patterns based on m1A regulators in the TCGA… read more here.
Keywords: modification; rna methyladenosine; mediated methylation; methyladenosine regulator ... See more keywords
RNA N6-Methyladenosine Modifications and Its Roles in Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.820378
Abstract: The importance of epitranscriptomics in regulating gene expression has received widespread attention. Recently, RNA methylation modifications, particularly N6-methyladenosine (m6A), have received marked attention. m6A, the most common and abundant type of eukaryotic methylation modification in… read more here.
Keywords: rna methyladenosine; modification; disease; alzheimer disease ... See more keywords
The Emerging Role of RNA N6-Methyladenosine Modification in Pancreatic Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.927640
Abstract: Pancreatic cancer (PC) is one of the most common malignant cancers, ranking the seventh highest causes of cancer-related deaths globally. Recently, RNA N6-methyladenosine (m6A) is emerging as one of the most abundant RNA modifications in… read more here.
Keywords: modification; rna methyladenosine; pancreatic cancer; m6a ... See more keywords
DNN-m6A: A Cross-Species Method for Identifying RNA N6-methyladenosine Sites Based on Deep Neural Network with Multi-Information Fusion
Sign Up to like & getrecommendations! Published in 2021 at "Genes"
DOI: 10.3390/genes12030354
Abstract: As a prevalent existing post-transcriptional modification of RNA, N6-methyladenosine (m6A) plays a crucial role in various biological processes. To better radically reveal its regulatory mechanism and provide new insights for drug design, the accurate identification… read more here.
Keywords: dnn m6a; method; cross; rna methyladenosine ... See more keywords