Messenger RNA Methylation Regulates Glioblastoma Tumorigenesis.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer cell"
DOI: 10.1016/j.ccell.2017.03.010
Abstract: Messenger RNA (mRNA) modification provides an additional layer of gene regulation in cells. In this issue of Cancer Cell, Zhang et al. report that ALKBH5, a demethylase of the mRNA modification N6-methyladenosine, regulates proliferation and self-renewal… read more here.
Keywords: rna methylation; glioblastoma tumorigenesis; messenger rna; messenger ... See more keywords
It's Not What You Say But How You Say It: Targeting RNA Methylation in AML.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.05.027
Abstract: In this month's issue of Cancer Cell, Su et al. (2020) describe two small-molecule inhibitors of the RNA demethylase FTO that demonstrate significant anti-tumor effects in various models of acute myeloid leukemia. read more here.
Keywords: targeting rna; rna methylation; say targeting; methylation aml ... See more keywords
Structural and evolutionary insights into ribosomal RNA methylation.
Sign Up to like & getrecommendations! Published in 2018 at "Nature chemical biology"
DOI: 10.1038/nchembio.2569
Abstract: Methylation of nucleotides in ribosomal RNAs (rRNAs) is a ubiquitous feature that occurs in all living organisms. Identification of all enzymes responsible for rRNA methylation, as well as mapping of all modified rRNA residues, is… read more here.
Keywords: rna methylation; methylation; ribosomal rna; evolutionary insights ... See more keywords
MTHFD2 links RNA methylation to metabolic reprogramming in renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Oncogene"
DOI: 10.1038/s41388-019-0869-4
Abstract: One-carbon metabolism plays a central role in a broad array of metabolic processes required for the survival and growth of tumor cells. However, the molecular basis of how one-carbon metabolism may influence RNA methylation and… read more here.
Keywords: rna methylation; methylation; renal cell; cell carcinoma ... See more keywords
m6A RNA methylation regulates the fate of endogenous retroviruses.
Sign Up to like & getrecommendations! Published in 2021 at "Nature"
DOI: 10.1038/s41586-020-03135-1
Abstract: Endogenous retroviruses (ERVs) are abundant and heterogenous groups of integrated retroviral sequences that affect genome regulation and cell physiology throughout their RNA-centred life cycle1. Failure to repress ERVs is associated with cancer, infertility, senescence and… read more here.
Keywords: rna methylation; methylation; endogenous retroviruses; mettl3 mettl14 ... See more keywords
Construction and validation of m6A RNA methylation regulators associated prognostic model for gastrointestinal cancer
Sign Up to like & getrecommendations! Published in 2022 at "IET Systems Biology"
DOI: 10.1049/syb2.12040
Abstract: Abstract N6‐methyladenosine (m6A) RNA methylation is correlated with carcinogenesis and dynamically possessed through the m6A RNA methylation regulators. This paper aimed to explore 13 m6A RNA methylation regulators' role in gastrointestinal cancer (GIC) and determine… read more here.
Keywords: m6a rna; rna methylation; methylation regulators; model ... See more keywords
RNA methylation and cellular response to oxidative stress-promoting anticancer agents
Sign Up to like & getrecommendations! Published in 2023 at "Cell Cycle"
DOI: 10.1080/15384101.2023.2165632
Abstract: ABSTRACT Disruption of the complex network that regulates redox homeostasis often underlies resistant phenotypes, which hinder effective and long-lasting cancer eradication. In addition, the RNA methylome-dependent control of gene expression also critically affects traits of… read more here.
Keywords: rna methylation; methylation cellular; oxidative stress; response ... See more keywords
Ibuprofen promotes p75 neurotrophin receptor expression through modifying promoter methylation and N6-methyladenosine-RNA-methylation in human gastric cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2092674
Abstract: ABSTRACT It is acknowledged that nonsteroidal anti-inflammatory drugs (NSAIDs) can participate in various signaling pathways, while information about their epigenetic effects are limited. p75NTR (p75 neurotrophin receptor) can inhibit tumor growth by inducing cell cycle… read more here.
Keywords: methylation; rna methylation; p75ntr; promoter methylation ... See more keywords
Evaluation of epitranscriptome-wide N6-methyladenosine differential analysis methods
Sign Up to like & getrecommendations! Published in 2023 at "Briefings in Bioinformatics"
DOI: 10.1093/bib/bbad139
Abstract: Abstract RNA methylation has emerged recently as an active research domain to study post-transcriptional alteration in gene expression regulation. Various types of RNA methylation, including N6-methyladenosine (m6A), are involved in human disease development. As a… read more here.
Keywords: rna methylation; evaluation epitranscriptome; wide methyladenosine; epitranscriptome wide ... See more keywords
Funm6AViewer: a web server and R package for functional analysis of context-specific m6A RNA methylation.
Sign Up to like & getrecommendations! Published in 2021 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btab362
Abstract: MOTIVATION N6-methyladenosine (m6A) is the most abundant mammalian mRNA methylation with versatile functions. To date, although a number of bioinformatics tools have been developed for location discovery of m6A modification, functional understanding is still quite… read more here.
Keywords: rna methylation; methylation; specific m6a; m6a ... See more keywords
P1621m6A RNA-methylation in the progression of heart failure
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz748.0380
Abstract: N6-Methyladenosine (m6A) is the most abundant modification of RNA and was found to be a dynamic and reversible process. It is found in many classes of RNA, such as mRNA, noncodingRNA (ncRNA) and microRNA (miR).… read more here.
Keywords: rna methylation; methylation; m6a rna; heart failure ... See more keywords