Discovery of substituted indole derivatives as allosteric inhibitors of m6A‐RNA methyltransferase, METTL3‐14 complex
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DOI: 10.1002/ddr.21910
Abstract: m6A RNA methyltransferase (METTL3‐14) catalyzes the methylation of adenosine in mRNA and plays important roles in mRNA functions, and it has been implicated in the progression of multiple cancers, including acute myeloid leukemia (AML). In… read more here.
Keywords: m6a rna; mettl3 complex; rna methyltransferase; methyltransferase mettl3 ... See more keywords
Recognition of G-quadruplex RNA by a crucial RNA methyltransferase component, METTL14
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DOI: 10.1093/nar/gkab1211
Abstract: Abstract N6-methyladenosine (m6A) is an important epitranscriptomic chemical modification that is mainly catalyzed by the METTL3/METTL14 RNA methyltransferase heterodimer. Although m6A is found at the consensus sequence of 5′-DRACH-3′ in various transcripts, the mechanism by… read more here.
Keywords: rna methyltransferase; mettl14; mettl3 mettl14; rna ... See more keywords
RNA methyltransferase METTL3 induces intrinsic resistance to gefitinib by combining with MET to regulate PI3K/AKT pathway in lung adenocarcinoma
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DOI: 10.1111/jcmm.16114
Abstract: Clinical research data show that gefitinib greatly improves the progression‐free survival of patients, so it is used in advanced non‐small cell lung cancer patients with EGFR mutation. However, some patients with EGFR sensitive mutations do… read more here.
Keywords: gefitinib; rna methyltransferase; pi3k akt; lung cancer ... See more keywords
RNA 2’-O-Methyltransferase Fibrillarin Facilitates Virus Entry Into Macrophages Through Inhibiting Type I Interferon Response
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DOI: 10.3389/fimmu.2022.793582
Abstract: Type I interferons (IFN-I) play crucial roles in antiviral immune responses through inducing multiple antiviral interferon stimulated genes (ISGs). RNA modifications are emerging as critical post-transcriptional regulators of gene expression programs, which affect diverse biological… read more here.
Keywords: entry; rna modifications; viral infection; interferon ... See more keywords