Coronaviral RNA-methyltransferases: function, structure and inhibition
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DOI: 10.1093/nar/gkab1279
Abstract: Abstract Coronaviral methyltransferases (MTases), nsp10/16 and nsp14, catalyze the last two steps of viral RNA-cap creation that takes place in cytoplasm. This cap is essential for the stability of viral RNA and, most importantly, for… read more here.
Keywords: structure; rna; rna methyltransferases; coronaviral rna ... See more keywords
Chemical biology and medicinal chemistry of RNA methyltransferases
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DOI: 10.1093/nar/gkac224
Abstract: Abstract RNA methyltransferases (MTases) are ubiquitous enzymes whose hitherto low profile in medicinal chemistry, contrasts with the surging interest in RNA methylation, the arguably most important aspect of the new field of epitranscriptomics. As MTases… read more here.
Keywords: chemical biology; medicinal chemistry; chemistry; rna methyltransferases ... See more keywords
Chemical Space Virtual Screening against Hard-to-Drug RNA Methyltransferases DNMT2 and NSUN6
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076109
Abstract: Targeting RNA methyltransferases with small molecules as inhibitors or tool compounds is an emerging field of interest in epitranscriptomics and medicinal chemistry. For two challenging RNA methyltransferases that introduce the 5-methylcytosine (m5C) modification in different… read more here.
Keywords: chemical space; dnmt2 nsun6; space virtual; rna methyltransferases ... See more keywords