RNA modification “writer”-mediated RNA modification patterns and tumor microenvironment characteristics of cervical cancer
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Translational Oncology"
DOI: 10.1007/s12094-022-02787-x
Abstract: As an epigenetic regulation mechanism after transcription, RNA modification is installed by endogenous "writer" enzymes and is widely involved in a variety of physiological processes, including cancer progression. This study explored the RNA modification patterns… read more here.
Keywords: cervical cancer; modification; rna modification; modification patterns ... See more keywords
Functional Dissection of the m6A RNA Modification.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in biochemical sciences"
DOI: 10.1016/j.tibs.2016.12.004
Abstract: Much work over the past three decades has established that chemical modifications of DNA and histones are intimately linked with various facets of DNA metabolism, most notably transcription. In addition to chromatin components, RNA has… read more here.
Keywords: functional dissection; rna; rna modification; m6a ... See more keywords
Single-Neuron RNA Modification Analysis by Mass Spectrometry: Characterizing RNA Modification Patterns and Dynamics with Single-Cell Resolution.
Sign Up to like & getrecommendations! Published in 2021 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c03507
Abstract: The entire collection of post-transcriptional modifications to RNA, known as the epitranscriptome, has been increasingly recognized as a critical regulatory layer in the cellular translation machinery. However, contemporary methods for the analysis of RNA modifications… read more here.
Keywords: analysis; rna modification; rna modifications; cell ... See more keywords
The RNA modification N6-methyladenosine as a novel regulator of the immune system
Sign Up to like & getrecommendations! Published in 2020 at "Nature Immunology"
DOI: 10.1038/s41590-020-0650-4
Abstract: Protection from harmful pathogens depends on activation of the immune system, which relies on tight regulation of gene expression. Recently, the RNA modification N6-methyladenosine (m6A) has been found to play an essential role in such… read more here.
Keywords: rna modification; immune system; modification methyladenosine;
5-methylcytosine (m5C) RNA modification controls the innate immune response to virus infection by regulating type I interferons
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2123338119
Abstract: Significance 5-methylcytosine (m5C) is a common RNA methylation. However, its biological functions remain a mystery. Here, we discover that depletion of NSUN2, an m5C methyltransferase, leads to an enhanced type I interferon (IFN) response, which… read more here.
Keywords: rna modification; m5c rna; rna; methylcytosine m5c ... See more keywords
Broad-range RNA modification analysis of complex biological samples using rapid C18-UPLC-MS
Sign Up to like & getrecommendations! Published in 2020 at "RNA Biology"
DOI: 10.1080/15476286.2020.1853385
Abstract: ABSTRACT Post-transcriptional RNA modifications play an important role in cellular metabolism with homoeostatic disturbances manifesting as a wide repertoire of phenotypes, reduced stress tolerance and translational perturbation, developmental defects, and diseases, such as type II… read more here.
Keywords: biological samples; complex biological; broad range; rna modification ... See more keywords
Multi-task adaptive pooling enabled synergetic learning of RNA modification across tissue, type and species from low-resolution epitranscriptomes.
Sign Up to like & getrecommendations! Published in 2023 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbad105
Abstract: Post- and co-transcriptional RNA modifications are found to play various roles in regulating essential biological processes at all stages of RNA life. Precise identification of RNA modification sites is thus crucial for understanding the related… read more here.
Keywords: modification; low resolution; rna modification; resolution ... See more keywords
RM2Target: a comprehensive database for targets of writers, erasers and readers of RNA modifications
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac945
Abstract: Abstract RNA modification is a dynamic and reversible process regulated by a series of writers, erasers and readers (WERs). Abnormal changes of WERs will disrupt the RNA modification homeostasis of their target genes, leading to… read more here.
Keywords: erasers readers; writers erasers; rna modification; database ... See more keywords
RNA Modification in the Immune System.
Sign Up to like & getrecommendations! Published in 2023 at "Annual review of immunology"
DOI: 10.1146/annurev-immunol-101921-045401
Abstract: Characterization of RNA modifications has identified their distribution features and molecular functions. Dynamic changes in RNA modification on various forms of RNA are essential for the development and function of the immune system. In this… read more here.
Keywords: modification; immune system; rna modification;
Integrative analyses of the RNA modification machinery reveal tissue- and cancer-specific signatures
Sign Up to like & getrecommendations! Published in 2020 at "Genome Biology"
DOI: 10.1186/s13059-020-02009-z
Abstract: Background RNA modifications play central roles in cellular fate and differentiation. However, the machinery responsible for placing, removing, and recognizing more than 170 RNA modifications remains largely uncharacterized and poorly annotated, and we currently lack… read more here.
Keywords: machinery; rna modification; rna modifications; expression ... See more keywords
N6-methyladenine RNA modification (m6A): an emerging regulator of metabolic diseases.
Sign Up to like & getrecommendations! Published in 2020 at "Current drug targets"
DOI: 10.2174/1389450121666200210125247
Abstract: N6-methyladenine RNA modification ( m6 A) is a RNA methylation modification catalyzed by methyltransferase at the 6th position nitrogen atom of adenine (A), which is the most common chemical modification of eukaryotic messenger RNA (mRNA).… read more here.
Keywords: metabolic diseases; methyladenine rna; rna modification; m6a ... See more keywords