RNA modification‐related EIF4G2 is an immunotherapy determinant in osteosarcoma: A single‐cell sequencing analysis
Sign Up to like & getrecommendations! Published in 2024 at "Environmental Toxicology"
DOI: 10.1002/tox.24261
Abstract: The clinical outcomes of osteosarcoma are relatively dismal. As immunotherapy has revolutionized treatment for solid tumors, exploring novel immunotherapy‐related therapeutic targets for osteosarcoma is important. In this study, we aimed to establish the connection between… read more here.
Keywords: osteosarcoma; immunotherapy; analysis; modification related ... See more keywords
Regulation of Skeletogenic Pathways by m6A RNA Modification: A Comprehensive Review
Sign Up to like & getrecommendations! Published in 2025 at "Calcified Tissue International"
DOI: 10.1007/s00223-025-01367-9
Abstract: In the complex process of skeletal development, the significance of m6A RNA methylation—a predominant form of RNA modification—has not been fully explored. This review discuss how m6A RNA methylation plays an important, though not yet… read more here.
Keywords: methylation; review; rna methylation; rna modification ... See more keywords
RNA modification regulators as promising biomarkers in gynecological cancers
Sign Up to like & getrecommendations! Published in 2024 at "Cell Biology and Toxicology"
DOI: 10.1007/s10565-024-09924-y
Abstract: This review explores the evolving landscape of gynecological oncology by focusing on emerging RNA modification signatures as promising biomarkers for assessing the risk and progression of ovarian, cervical, and uterine cancers. It provides a comprehensive… read more here.
Keywords: oncology; modification regulators; promising biomarkers; rna modifications ... See more keywords
RNA modification “writer”-mediated RNA modification patterns and tumor microenvironment characteristics of cervical cancer
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Translational Oncology"
DOI: 10.1007/s12094-022-02787-x
Abstract: As an epigenetic regulation mechanism after transcription, RNA modification is installed by endogenous "writer" enzymes and is widely involved in a variety of physiological processes, including cancer progression. This study explored the RNA modification patterns… read more here.
Keywords: cervical cancer; modification; rna modification; modification patterns ... See more keywords
Functional Dissection of the m6A RNA Modification.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in biochemical sciences"
DOI: 10.1016/j.tibs.2016.12.004
Abstract: Much work over the past three decades has established that chemical modifications of DNA and histones are intimately linked with various facets of DNA metabolism, most notably transcription. In addition to chromatin components, RNA has… read more here.
Keywords: functional dissection; rna; rna modification; m6a ... See more keywords
Single-Neuron RNA Modification Analysis by Mass Spectrometry: Characterizing RNA Modification Patterns and Dynamics with Single-Cell Resolution.
Sign Up to like & getrecommendations! Published in 2021 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c03507
Abstract: The entire collection of post-transcriptional modifications to RNA, known as the epitranscriptome, has been increasingly recognized as a critical regulatory layer in the cellular translation machinery. However, contemporary methods for the analysis of RNA modifications… read more here.
Keywords: analysis; rna modification; rna modifications; cell ... See more keywords
Emerging role of RNA modification and long noncoding RNA interaction in cancer
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Gene Therapy"
DOI: 10.1038/s41417-024-00734-2
Abstract: RNA modification, especially N6-methyladenosine, 5-methylcytosine, and N7-methylguanosine methylation, participates in the occurrence and progression of cancer through multiple pathways. The function and expression of these epigenetic regulators have gradually become a hot topic in cancer… read more here.
Keywords: cancer; rna modification; interaction cancer; noncoding rna ... See more keywords
An RNA modification prevents extended codon-anticodon interactions from facilitating +1 frameshifting
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-62342-4
Abstract: RNA post-transcriptional modifications act by stabilizing the functional conformations of RNA. While their role in messenger RNA (mRNA) decoding is well established, it is less clear how transfer RNA (tRNA) modifications outside the anticodon contribute… read more here.
Keywords: codon anticodon; rna modification; prevents extended; modification prevents ... See more keywords
Basis for selective drug evasion of an aminoglycoside-resistance ribosomal RNA modification
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-63278-5
Abstract: Aminoglycosides disrupt the fidelity of bacterial protein synthesis, but their potent antibacterial activity is threatened by multiple resistance mechanisms, including methylation of their ribosomal RNA (rRNA) binding site. However, the impact of one such resistance-conferring… read more here.
Keywords: resistance; rna; evasion; rna modification ... See more keywords
The RNA modification N6-methyladenosine as a novel regulator of the immune system
Sign Up to like & getrecommendations! Published in 2020 at "Nature Immunology"
DOI: 10.1038/s41590-020-0650-4
Abstract: Protection from harmful pathogens depends on activation of the immune system, which relies on tight regulation of gene expression. Recently, the RNA modification N6-methyladenosine (m6A) has been found to play an essential role in such… read more here.
Keywords: rna modification; immune system; modification methyladenosine;
5-methylcytosine (m5C) RNA modification controls the innate immune response to virus infection by regulating type I interferons
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2123338119
Abstract: Significance 5-methylcytosine (m5C) is a common RNA methylation. However, its biological functions remain a mystery. Here, we discover that depletion of NSUN2, an m5C methyltransferase, leads to an enhanced type I interferon (IFN) response, which… read more here.
Keywords: rna modification; m5c rna; rna; methylcytosine m5c ... See more keywords