RNA Modifications Shape Hematopoietic Stem Cell Aging: Beyond the Code
Sign Up to like & getrecommendations! Published in 2024 at "Febs Letters"
DOI: 10.1002/1873-3468.15014
Abstract: Hematopoietic system aging is characterized by both hematopoietic stem cell (HSC) and niche degeneration resulting in myeloid lineage‐biased differentiation, reduced B cell and T cell lymphopoiesis, increased HSC mobilization, and fat deposition in the bone… read more here.
Keywords: modifications shape; hematopoietic stem; stem cell; cell ... See more keywords
High‐throughput detection of RNA modifications at single base resolution
Sign Up to like & getrecommendations! Published in 2024 at "Febs Letters"
DOI: 10.1002/1873-3468.15052
Abstract: RNA is modified by > 170 chemical modifications that affect its structure and function. Accordingly, RNA modifications have been implicated in regulation of gene expression and cellular outcomes in a variety of species spanning the phylogenetic… read more here.
Keywords: high throughput; base resolution; single base; rna ... See more keywords
Characterization of RNA modifications in gastric cancer to identify prognosis‐relevant gene signatures
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4861
Abstract: Most human genes have diverse transcript isoforms, which mainly arise from alternative cleavage and polyadenylation (APA) at 3′ ends. N7‐methylguanosine (m7G) is also an essential epigenetic modification at the 5′ end. However, the contribution of… read more here.
Keywords: prognosis; modifications gastric; characterization rna; gastric cancer ... See more keywords
Targeting RNA modifications with pharmacological agents: New frontiers in cancer therapy
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Medicine"
DOI: 10.1002/cam4.6989
Abstract: The N6‐methyladenosine (m6A) RNA modification has gained significant prominence as a new layer of regulatory mechanism that governs gene expression. Over the past decade, various m6A regulators responsible for introducing, eliminating, and recognising RNA methylation… read more here.
Keywords: m6a regulators; cancer; m6a; rna modifications ... See more keywords
The Profile and Dynamics of RNA Modifications in Animals
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DOI: 10.1002/cbic.201700093
Abstract: More than a hundred distinct modified nucleosides have been identified in RNA, but little is known about their distribution across different organisms, their dynamic nature and their response to cellular and environmental stress. Mass‐spectrometry‐based methods… read more here.
Keywords: modified nucleosides; dynamics rna; modifications animals; profile dynamics ... See more keywords
Cancer‐Specific RNA Modifications in Tumour‐Derived Extracellular Vesicles Promote Tumour Growth
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.70083
Abstract: ABSTRACT RNA modifications are crucial in cellular processes, and their dysregulation is linked to diseases like cancer. Extracellular vesicles (EVs) contain various RNAs and might be susceptible to modifications, but detecting these modifications has been… read more here.
Keywords: extracellular vesicles; cancer; cancer specific; tumour growth ... See more keywords
RNA Modifications and Their Role in Regulating KSHV Replication and Pathogenic Mechanisms
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Medical Virology"
DOI: 10.1002/jmv.70140
Abstract: Kaposi's sarcoma‐associated herpesvirus is an oncogenic gammaherpesvirus that plays a major role in several human malignancies, including Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. The complexity of KSHV biology is reflected in the… read more here.
Keywords: replication; role; rna modifications; modifications role ... See more keywords
A molecular‐level perspective on the frequency, distribution, and consequences of messenger RNA modifications
Sign Up to like & getrecommendations! Published in 2020 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1586
Abstract: Cells use chemical modifications to alter the sterics, charge, and conformations of large biomolecules, modulating their biogenesis, function, and stability. Until recently post‐transcriptional RNA modifications were thought to be largely limited to nonprotein coding RNA… read more here.
Keywords: molecular level; frequency; mrna modifications; rna modifications ... See more keywords
The emergent role of mitochondrial RNA modifications in metabolic alterations
Sign Up to like & getrecommendations! Published in 2022 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1753
Abstract: Mitochondrial epitranscriptomics refers to the modifications occurring in all the different RNA types of mitochondria. Although the number of mitochondrial RNA modifications is less than those in cytoplasm, substantial evidence indicates that they play a… read more here.
Keywords: mitochondrial rna; rna modifications; emergent role; metabolic alterations ... See more keywords
RNA modification regulators as promising biomarkers in gynecological cancers
Sign Up to like & getrecommendations! Published in 2024 at "Cell Biology and Toxicology"
DOI: 10.1007/s10565-024-09924-y
Abstract: This review explores the evolving landscape of gynecological oncology by focusing on emerging RNA modification signatures as promising biomarkers for assessing the risk and progression of ovarian, cervical, and uterine cancers. It provides a comprehensive… read more here.
Keywords: oncology; modification regulators; promising biomarkers; rna modifications ... See more keywords
Quantifying the influence of 5'-RNA modifications on RNA polymerase I activity.
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical chemistry"
DOI: 10.1016/j.bpc.2017.08.010
Abstract: For ensemble and single-molecule analyses of transcription, the use of synthetic transcription elongation complexes has been a versatile and powerful tool. However, structural analyses demonstrate that short RNA substrates, often employed in these assays, would… read more here.
Keywords: influence rna; rna; rna polymerase; rna modifications ... See more keywords