Characterization of RNA modifications in gastric cancer to identify prognosis‐relevant gene signatures
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4861
Abstract: Most human genes have diverse transcript isoforms, which mainly arise from alternative cleavage and polyadenylation (APA) at 3′ ends. N7‐methylguanosine (m7G) is also an essential epigenetic modification at the 5′ end. However, the contribution of… read more here.
Keywords: prognosis; modifications gastric; characterization rna; gastric cancer ... See more keywords
The Profile and Dynamics of RNA Modifications in Animals
Sign Up to like & getrecommendations! Published in 2017 at "Chembiochem"
DOI: 10.1002/cbic.201700093
Abstract: More than a hundred distinct modified nucleosides have been identified in RNA, but little is known about their distribution across different organisms, their dynamic nature and their response to cellular and environmental stress. Mass‐spectrometry‐based methods… read more here.
Keywords: modified nucleosides; dynamics rna; modifications animals; profile dynamics ... See more keywords
A molecular‐level perspective on the frequency, distribution, and consequences of messenger RNA modifications
Sign Up to like & getrecommendations! Published in 2020 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1586
Abstract: Cells use chemical modifications to alter the sterics, charge, and conformations of large biomolecules, modulating their biogenesis, function, and stability. Until recently post‐transcriptional RNA modifications were thought to be largely limited to nonprotein coding RNA… read more here.
Keywords: molecular level; frequency; mrna modifications; rna modifications ... See more keywords
The emergent role of mitochondrial RNA modifications in metabolic alterations
Sign Up to like & getrecommendations! Published in 2022 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1753
Abstract: Mitochondrial epitranscriptomics refers to the modifications occurring in all the different RNA types of mitochondria. Although the number of mitochondrial RNA modifications is less than those in cytoplasm, substantial evidence indicates that they play a… read more here.
Keywords: mitochondrial rna; rna modifications; emergent role; metabolic alterations ... See more keywords
Quantifying the influence of 5'-RNA modifications on RNA polymerase I activity.
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical chemistry"
DOI: 10.1016/j.bpc.2017.08.010
Abstract: For ensemble and single-molecule analyses of transcription, the use of synthetic transcription elongation complexes has been a versatile and powerful tool. However, structural analyses demonstrate that short RNA substrates, often employed in these assays, would… read more here.
Keywords: influence rna; rna; rna polymerase; rna modifications ... See more keywords
Adolescent alcohol exposure alters DNA and RNA modifications in peripheral blood by liquid chromatography-tandem mass spectrometry analysis
Sign Up to like & getrecommendations! Published in 2021 at "Chinese Chemical Letters"
DOI: 10.1016/j.cclet.2021.08.094
Abstract: ABSTRACT Alcohol consumption is a critical risk factor contributing to a verity of human diseases. The incidence of alcohol use disorder increases across adolescence in recent years. Accumulating line of evidence suggests that alcohol-induced changes… read more here.
Keywords: rna modifications; alcohol exposure; dna rna;
Emerging role of dynamic RNA modifications during animal development
Sign Up to like & getrecommendations! Published in 2018 at "Mechanisms of development"
DOI: 10.1016/j.mod.2018.04.002
Abstract: The central dogma of molecular biology statically says that the information flows from DNA to messenger RNA to protein. But the recent advances in mass spectrometry and high throughput technology have helped the scientists to… read more here.
Keywords: development emerging; emerging role; rna modifications; animal development ... See more keywords
RNA modifications in structure prediction - Status quo and future challenges.
Sign Up to like & getrecommendations! Published in 2019 at "Methods"
DOI: 10.1016/j.ymeth.2018.10.019
Abstract: Chemical modifications of RNA nucleotides change their identity and characteristics and thus alter genetic and structural information encoded in the genomic DNA. tRNA and rRNA are probably the most heavily modified genes, and often depend… read more here.
Keywords: rna modifications; prediction status; structure prediction; modifications structure ... See more keywords
Harnessing Nature's Molecular Recognition Capabilities to Map and Study RNA Modifications.
Sign Up to like & getrecommendations! Published in 2022 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.2c00287
Abstract: ConspectusRNA editing or "epitranscriptomic modification" refers to the processing of RNA that occurs after transcription to alter the sequence or structure of the nucleic acid. These chemical alterations can be found on either the ribose… read more here.
Keywords: rna; recognition capabilities; nature; molecular recognition ... See more keywords
Single-Neuron RNA Modification Analysis by Mass Spectrometry: Characterizing RNA Modification Patterns and Dynamics with Single-Cell Resolution.
Sign Up to like & getrecommendations! Published in 2021 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c03507
Abstract: The entire collection of post-transcriptional modifications to RNA, known as the epitranscriptome, has been increasingly recognized as a critical regulatory layer in the cellular translation machinery. However, contemporary methods for the analysis of RNA modifications… read more here.
Keywords: analysis; rna modification; rna modifications; cell ... See more keywords
Selective Chemical Labeling Strategy for Oligonucleotides Determination: A First Application to Full-Range Profiling of Transfer RNA Modifications.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c02302
Abstract: To date, the extremely high polarity and poor signal intensity of macromolecular nucleic acids are greatly impeding the progress of mass spectrometry technology in the quality control of nucleic acid drugs and the characterization of… read more here.
Keywords: rna; full range; range profiling; determination ... See more keywords