Toward RNA nanoparticle vaccines: synergizing RNA and inorganic nanoparticles to achieve immunopotentiation.
Sign Up to like & getrecommendations! Published in 2017 at "Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology"
DOI: 10.1002/wnan.1415
Abstract: Traditionally, vaccines have been composed of live attenuated or killed microorganisms. Alternatively, individual protein subunits or other molecular components of the microorganism can serve as the antigen and trigger an antibody response by the immune… read more here.
Keywords: vaccines synergizing; rna nanoparticle; synergizing rna; nanoparticle ... See more keywords
Self-Assembling RNA Nanoparticle for Gene Expression Regulation in a Model System.
Sign Up to like & getrecommendations! Published in 2019 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.8b00319
Abstract: In the search for enzymatically processed RNA fragments, we found the novel three-way junction motif. The structure prediction suggested the arrangement of helices at acute angle approx. 60°. This allows the design of a trimeric RNA… read more here.
Keywords: rna nanoparticle; nanoparticle; gene expression; gene ... See more keywords
An RNA nanoparticle vaccine against Zika virus elicits antibody and CD8+ T cell responses in a mouse model
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-00193-w
Abstract: The Zika virus (ZIKV) outbreak in the Americas and South Pacific poses a significant burden on human health because of ZIKV’s neurotropic effects in the course of fetal development. Vaccine candidates against ZIKV are coming… read more here.
Keywords: cd8 cell; rna nanoparticle; cell responses; vaccine ... See more keywords