Cyclodextrin-mediated formation of porous RNA nanospheres and their application in synergistic targeted therapeutics of hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2020.120304
Abstract: Spherical and porous nanoparticles are ideal nanostructures for drug delivery. But currently they are mainly composed of non-degradable inorganic materials, which hinder clinical applications. Here, biological porous nanospheres using RNA as the building blocks and… read more here.
Keywords: hepatocellular carcinoma; cyclodextrin; porous nanospheres; rna ... See more keywords
Self-assembled small messenger RNA nanospheres for efficient therapeutic apoptin expression and synergistic Gene-Chemotherapy of breast cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of colloid and interface science"
DOI: 10.1016/j.jcis.2021.06.061
Abstract: In this work, small self-assembled messenger RNA nanospheres (mRNA-NSs) were successfully prepared by rolling circle transcription on a constructed apoptin plasmid. The self-assembled mRNA-NSs have a uniform diameter of approximately 65 nm, good dispersity in solution,… read more here.
Keywords: mrna nss; self assembled; breast cancer; self ... See more keywords