Design and Crystallography of Self-Assembling RNA Nanostructures.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7138-1_9
Abstract: Biological RNA architectures are composed of autonomously folding modules which can be tailored as building blocks for the construction of RNA nanostructures. Designed base pair interactions allow complex nano-objects to self-assemble from simple RNA motifs.… read more here.
Keywords: rna nanostructures; self assembling; design crystallography; rna ... See more keywords
Gold Nanoparticles as Carriers for Functional RNA Nanostructures.
Sign Up to like & getrecommendations! Published in 2021 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.1c00211
Abstract: Conjugates of gold nanoparticles and ribonucleic acid are particularly interesting for biological applications to serve as therapeutics or biosensors. In this paper we present, for the first time, a conjugate of gold nanoparticles and structural… read more here.
Keywords: nanoparticles carriers; rna nanostructures; gold nanoparticles; functional rna ... See more keywords
RNA Nanostructures: From Structure to Function.
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.2c00417
Abstract: Nucleic-acid nanostructures, which have been designed and constructed with atomic precision, have been used as scaffolds for different molecules and proteins, as nanomachines, as computational components, and more. In particular, RNA has garnered tremendous interest… read more here.
Keywords: structure function; chemistry; rna; rna nanostructures ... See more keywords
Enzymatic Synthesis of Self-assembled Dicer Substrate RNA Nanostructures for Programmable Gene Silencing.
Sign Up to like & getrecommendations! Published in 2018 at "Nano letters"
DOI: 10.1021/acs.nanolett.8b01267
Abstract: Enzymatic synthesis of RNA nanostructures is achieved by isothermal rolling circle transcription (RCT). Each arm of RNA nanostructures provides a functional role of Dicer substrate RNA inducing sequence specific RNA interference (RNAi). Three different RNAi… read more here.
Keywords: rna nanostructures; enzymatic synthesis; rna; substrate rna ... See more keywords
In vivo production of RNA nanostructures via programmed folding of single-stranded RNAs
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-04652-4
Abstract: Programmed self-assembly of nucleic acids is a powerful approach for nano-constructions. The assembled nanostructures have been explored for various applications. However, nucleic acid assembly often requires chemical or in vitro enzymatical synthesis of DNA or… read more here.
Keywords: single stranded; rna nanostructures; rna; vivo production ... See more keywords
Hybrid DNA/RNA nanostructures with 2'-5' linkages.
Sign Up to like & getrecommendations! Published in 2020 at "Nanoscale"
DOI: 10.1039/d0nr05846g
Abstract: Nucleic acid nanostructures with different chemical compositions have shown utility in biological applications as they provide additional assembly parameters and enhanced stability. The naturally occurring 2'-5' linkage in RNA is thought to be a prebiotic… read more here.
Keywords: rna nanostructures; dna; rna; dna rna ... See more keywords
Design, optimization and analysis of large DNA and RNA nanostructures through interactive visualization, editing and molecular simulation
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa417
Abstract: Abstract This work seeks to remedy two deficiencies in the current nucleic acid nanotechnology software environment: the lack of both a fast and user-friendly visualization tool and a standard for structural analyses of simulated systems.… read more here.
Keywords: rna nanostructures; dna; analysis; large dna ... See more keywords
Challenges to optimizing RNA nanostructures for large scale production and controlled therapeutic properties.
Sign Up to like & getrecommendations! Published in 2020 at "Nanomedicine"
DOI: 10.2217/nnm-2020-0034
Abstract: Nucleic acids have been utilized to construct an expansive collection of nanoarchitectures varying in design, physicochemical properties, cellular processing and biomedical applications. However, the broader therapeutic adaptation of nucleic acid nanoassemblies in general, and RNA-based nanoparticles… read more here.
Keywords: rna nanostructures; optimizing rna; production; nanostructures large ... See more keywords