Bridging mRNA and Polycation using RNA Oligonucleotide Derivatives Improves the Robustness of Polyplex Micelles for Efficient mRNA Delivery.
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DOI: 10.1002/adhm.202102016
Abstract: Polyplex for mRNA delivery requires strong yet reversible association between mRNA and polycation for extracellular robustness and selective intracellular disintegration. Herein, RNA oligonucleotide (OligoRNA) derivatives that bridge mRNA and polycation are developed to stabilize polyplex… read more here.
Keywords: polyplex micelles; mrna delivery; rna oligonucleotide; polycation ... See more keywords
Preparation of Labeled DNA, RNA, and Oligonucleotide Probes.
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DOI: 10.1101/pdb.top100578
Abstract: Labeled nucleic acids and oligonucleotides are typically generated by enzymatic methods such as end-labeling, random priming, nick translation, in vitro transcription, and variations of the polymerase chain reaction (PCR). Some of these methods place the… read more here.
Keywords: rna oligonucleotide; oligonucleotide probes; labeled dna; preparation labeled ... See more keywords
Conformational heterogeneity of UCAAUC RNA oligonucleotide from molecular dynamics simulations, SAXS, and NMR experiments
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DOI: 10.1261/rna.078888.121
Abstract: We describe the conformational ensemble of the single-stranded r(UCAAUC) oligonucleotide obtained using extensive molecular dynamics (MD) simulations and Rosetta's FARFAR2 algorithm. The conformations observed in MD consist of A-form-like structures and variations thereof. These structures… read more here.
Keywords: dynamics simulations; rna oligonucleotide; heterogeneity ucaauc; ucaauc rna ... See more keywords