Induced packaging of mRNA into polyplex micelles by regulated hybridization with a small number of cholesteryl RNA oligonucleotides directed enhanced in vivo transfection.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2019.01.023
Abstract: There has been a progressive interest in the molecular design of polymers and lipids as synthetic carriers for targeting therapeutic mRNA in vivo with the ability to circumvent nuclease attack for treating intractable diseases. Herein,… read more here.
Keywords: rna oligonucleotides; chol oligorna; polyplex micelles; cholesteryl ... See more keywords
Reducible Branched Ester-Amine Quadpolymers (rBEAQs) Codelivering Plasmid DNA and RNA Oligonucleotides Enable CRISPR/Cas9 Genome Editing.
Sign Up to like & getrecommendations! Published in 2019 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.8b20206
Abstract: Functional codelivery of plasmid DNA and RNA oligonucleotides in the same nanoparticle system is challenging due to differences in their physical properties as well as their intracellular locations of function. In this study, we synthesized… read more here.
Keywords: rna oligonucleotides; dna; plasmid dna; dna rna ... See more keywords
Photochemical modifications for DNA/RNA oligonucleotides
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d1ra05951c
Abstract: Light-triggered chemical reactions can provide excellent tools to investigate the fundamental mechanisms important in biology. Light is easily applicable and orthogonal to most cellular events, and its dose and locality can be controlled in tissues… read more here.
Keywords: modifications dna; photochemical modifications; rna oligonucleotides; biology ... See more keywords
Circular RNA oligonucleotides: enzymatic synthesis and scaffolding for nanoconstruction.
Sign Up to like & getrecommendations! Published in 2024 at "Nanoscale horizons"
DOI: 10.1039/d4nh00236a
Abstract: We report the efficient synthesis of monomeric circular RNAs (circRNAs) in the size range of 16-44 nt with a novel DNA dumbbell splinting plus T4 DNA ligation strategy. Such a DNA dumbbell splinting strategy was… read more here.
Keywords: oligonucleotides enzymatic; rna oligonucleotides; enzymatic synthesis; rna ... See more keywords
A convenient solid phase approach to obtain lipophilic 5′-phosphoramidate derivatives of DNA and RNA oligonucleotides
Sign Up to like & getrecommendations! Published in 2018 at "Nucleosides, Nucleotides and Nucleic Acids"
DOI: 10.1080/15257770.2017.1421765
Abstract: ABSTRACT This paper explores the potential of a modified phosphotriester approach to the synthesis of 5′-phosphoramidate derivatives of DNA and RNA oligonucleotides. The modification of 5′-deprotected support-bound oligonucleotides is done in two steps: i) conversion… read more here.
Keywords: rna oligonucleotides; derivatives dna; phosphoramidate derivatives; solid phase ... See more keywords