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Published in 2019 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2019.01.023
Abstract: There has been a progressive interest in the molecular design of polymers and lipids as synthetic carriers for targeting therapeutic mRNA in vivo with the ability to circumvent nuclease attack for treating intractable diseases. Herein,…
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Keywords:
rna oligonucleotides;
chol oligorna;
polyplex micelles;
cholesteryl ... See more keywords
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Published in 2019 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.8b20206
Abstract: Functional codelivery of plasmid DNA and RNA oligonucleotides in the same nanoparticle system is challenging due to differences in their physical properties as well as their intracellular locations of function. In this study, we synthesized…
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Keywords:
rna oligonucleotides;
dna;
plasmid dna;
dna rna ... See more keywords
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Published in 2022 at "RSC Advances"
DOI: 10.1039/d1ra05951c
Abstract: Light-triggered chemical reactions can provide excellent tools to investigate the fundamental mechanisms important in biology. Light is easily applicable and orthogonal to most cellular events, and its dose and locality can be controlled in tissues…
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Keywords:
modifications dna;
photochemical modifications;
rna oligonucleotides;
biology ... See more keywords
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Published in 2018 at "Nucleosides, Nucleotides and Nucleic Acids"
DOI: 10.1080/15257770.2017.1421765
Abstract: ABSTRACT This paper explores the potential of a modified phosphotriester approach to the synthesis of 5′-phosphoramidate derivatives of DNA and RNA oligonucleotides. The modification of 5′-deprotected support-bound oligonucleotides is done in two steps: i) conversion…
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Keywords:
rna oligonucleotides;
derivatives dna;
phosphoramidate derivatives;
solid phase ... See more keywords