Regulatory Role of N6‐methyladenosine (m6A) Methylation in RNA Processing and Human Diseases
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25967
Abstract: N6‐methyladenosine (m6A) modification is an abundant and conservative RNA modification in bacterial and eukaryotic cells. m6A modification mainly occurs in the 3′ untranslated regions (UTRs) and near the stop codons of mRNA. Diverse strategies have… read more here.
Keywords: methyladenosine m6a; m6a modification; rna processing; m6a ... See more keywords
Analysis of Mitochondrial RNA-Processing Defects in Patient-Derived Tissues by qRT-PCR and RNAseq.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6824-4_23
Abstract: Transcription of the mitochondrial genome yields three large polycistronic transcripts that undergo multiple endonucleolytic processing steps, before resulting in functional mRNAs, tRNAs, and rRNAs. Cleavage of the large precursor transcripts is mainly performed by the… read more here.
Keywords: pcr rnaseq; processing; rnase; rna processing ... See more keywords
Nuclease integrated kinase super assemblies (NiKs) and their role in RNA processing
Sign Up to like & getrecommendations! Published in 2017 at "Current Genetics"
DOI: 10.1007/s00294-017-0749-9
Abstract: Here we highlight the Grc3/Las1 complex, an essential RNA processing machine that is well conserved across eukaryotes and required for processing the pre-ribosomal RNA (pre-rRNA). Las1 is an endoribonuclease that cleaves the pre-rRNA while Grc3… read more here.
Keywords: grc3 las1; kinase; rna; nuclease integrated ... See more keywords
ERH proteins: connecting RNA processing to tumorigenesis?
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DOI: 10.1007/s00294-020-01065-z
Abstract: With the development of -omics approaches, the scientific community is now submerged by a wealth of information that can be used to analyze various parameters: the degree of protein sequence conservation, protein 3D structures as… read more here.
Keywords: protein; erh proteins; connecting rna; proteins connecting ... See more keywords
RNA processing as an alternative route to attack glioblastoma
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DOI: 10.1007/s00439-017-1819-2
Abstract: AbstractGenomic analyses have become an important tool to identify new avenues for therapy. This is especially true for cancer types with extremely poor outcomes, since our lack of effective therapies offers no tangible clinical starting… read more here.
Keywords: glioblastoma; processing alternative; rna processing; cancer ... See more keywords
Chemical Biology Toolkit for DCLK1 Reveals Connection to RNA Processing.
Sign Up to like & getrecommendations! Published in 2020 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2020.07.011
Abstract: Doublecortin-like kinase 1 (DCLK1) is critical for neurogenesis, but overexpression is also observed in multiple cancers and is associated with poor prognosis. Nevertheless, the function of DCLK1 in cancer, especially the context-dependent functions, are poorly… read more here.
Keywords: biology toolkit; chemical biology; rna processing; biology ... See more keywords
Homozygous n.64C>T mutation in mitochondrial RNA-processing endoribonuclease gene causes Cartilage Hair Hypoplasia Syndrome in two siblings.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medical genetics"
DOI: 10.1016/j.ejmg.2021.104136
Abstract: Cartilage hair hypoplasia syndrome (OMIM # 250250) is a rare autosomal recessive metaphyseal dysplasia, characterized by disproportionate short stature, hair hypoplasia and variable extra-skeletal manifestations, including immunodeficiency, anemia, intestinal diseases and predisposition to cancers. Cartilage… read more here.
Keywords: mutation mitochondrial; cartilage hair; hypoplasia syndrome; rna processing ... See more keywords
Lexis and Grammar of Mitochondrial RNA Processing in Trypanosomes.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in parasitology"
DOI: 10.1016/j.pt.2020.01.006
Abstract: Trypanosoma brucei spp. cause African human and animal trypanosomiasis, a burden on health and economy in Africa. These hemoflagellates are distinguished by a kinetoplast nucleoid containing mitochondrial DNAs of two kinds: maxicircles encoding ribosomal RNAs… read more here.
Keywords: grammar mitochondrial; rna; lexis grammar; rna processing ... See more keywords
The roles of RNA processing in translating genotype to phenotype
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Molecular Cell Biology"
DOI: 10.1038/nrm.2016.139
Abstract: A goal of human genetics studies is to determine the mechanisms by which genetic variation produces phenotypic differences that affect human health. Efforts in this respect have previously focused on genetic variants that affect mRNA… read more here.
Keywords: processing translating; variants affect; genotype phenotype; translating genotype ... See more keywords
Noncoding RNA processing by DIS3 regulates chromosomal architecture and somatic hypermutation in B cells
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DOI: 10.1038/s41588-020-00772-0
Abstract: Noncoding RNAs are exquisitely titrated by the cellular RNA surveillance machinery for regulating diverse biological processes. The RNA exosome, the predominant 3′ RNA exoribonuclease in mammalian cells, is composed of nine core and two catalytic… read more here.
Keywords: noncoding rna; rna; rna processing; dis3 ... See more keywords
Revealing nascent RNA processing dynamics with nano-COP.
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DOI: 10.1038/s41596-020-00469-y
Abstract: During maturation, eukaryotic precursor RNAs undergo processing events including intron splicing, 3'-end cleavage, and polyadenylation. Here we describe nanopore analysis of co-transcriptional processing (nano-COP), a method for probing the timing and patterns of RNA processing.… read more here.
Keywords: transcription; rna; nascent rna; nano cop ... See more keywords