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   Articles with "rna processing" as a keyword



Regulatory Role of N6‐methyladenosine (m6A) Methylation in RNA Processing and Human Diseases

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recommendations! Published in 2017 at "Journal of Cellular Biochemistry"

DOI: 10.1002/jcb.25967

Abstract: N6‐methyladenosine (m6A) modification is an abundant and conservative RNA modification in bacterial and eukaryotic cells. m6A modification mainly occurs in the 3′ untranslated regions (UTRs) and near the stop codons of mRNA. Diverse strategies have… read more here.

Keywords: methyladenosine m6a; m6a modification; rna processing; m6a ... See more keywords

Analysis of Mitochondrial RNA-Processing Defects in Patient-Derived Tissues by qRT-PCR and RNAseq.

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recommendations! Published in 2017 at "Methods in molecular biology"

DOI: 10.1007/978-1-4939-6824-4_23

Abstract: Transcription of the mitochondrial genome yields three large polycistronic transcripts that undergo multiple endonucleolytic processing steps, before resulting in functional mRNAs, tRNAs, and rRNAs. Cleavage of the large precursor transcripts is mainly performed by the… read more here.

Keywords: pcr rnaseq; processing; rnase; rna processing ... See more keywords

Nuclease integrated kinase super assemblies (NiKs) and their role in RNA processing

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recommendations! Published in 2017 at "Current Genetics"

DOI: 10.1007/s00294-017-0749-9

Abstract: Here we highlight the Grc3/Las1 complex, an essential RNA processing machine that is well conserved across eukaryotes and required for processing the pre-ribosomal RNA (pre-rRNA). Las1 is an endoribonuclease that cleaves the pre-rRNA while Grc3… read more here.

Keywords: grc3 las1; kinase; rna; nuclease integrated ... See more keywords
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ERH proteins: connecting RNA processing to tumorigenesis?

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recommendations! Published in 2020 at "Current Genetics"

DOI: 10.1007/s00294-020-01065-z

Abstract: With the development of -omics approaches, the scientific community is now submerged by a wealth of information that can be used to analyze various parameters: the degree of protein sequence conservation, protein 3D structures as… read more here.

Keywords: protein; erh proteins; connecting rna; proteins connecting ... See more keywords

RNA processing as an alternative route to attack glioblastoma

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recommendations! Published in 2017 at "Human Genetics"

DOI: 10.1007/s00439-017-1819-2

Abstract: AbstractGenomic analyses have become an important tool to identify new avenues for therapy. This is especially true for cancer types with extremely poor outcomes, since our lack of effective therapies offers no tangible clinical starting… read more here.

Keywords: glioblastoma; processing alternative; rna processing; cancer ... See more keywords

TOB1 and TOB2 mark distinct RNA processing granules in differentiating lens fiber cells

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recommendations! Published in 2024 at "Journal of Molecular Histology"

DOI: 10.1007/s10735-023-10177-y

Abstract: Differentiation of lens fiber cells involves a complex interplay of signals from growth factors together with tightly regulated gene expression via transcriptional and post-transcriptional regulators. Various studies have demonstrated that RNA-binding proteins, functioning in ribonucleoprotein… read more here.

Keywords: tob1 tob2; fiber cells; lens fiber; rna processing ... See more keywords
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Chemical Biology Toolkit for DCLK1 Reveals Connection to RNA Processing.

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recommendations! Published in 2020 at "Cell chemical biology"

DOI: 10.1016/j.chembiol.2020.07.011

Abstract: Doublecortin-like kinase 1 (DCLK1) is critical for neurogenesis, but overexpression is also observed in multiple cancers and is associated with poor prognosis. Nevertheless, the function of DCLK1 in cancer, especially the context-dependent functions, are poorly… read more here.

Keywords: biology toolkit; chemical biology; rna processing; biology ... See more keywords
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Homozygous n.64C>T mutation in mitochondrial RNA-processing endoribonuclease gene causes Cartilage Hair Hypoplasia Syndrome in two siblings.

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recommendations! Published in 2021 at "European journal of medical genetics"

DOI: 10.1016/j.ejmg.2021.104136

Abstract: Cartilage hair hypoplasia syndrome (OMIM # 250250) is a rare autosomal recessive metaphyseal dysplasia, characterized by disproportionate short stature, hair hypoplasia and variable extra-skeletal manifestations, including immunodeficiency, anemia, intestinal diseases and predisposition to cancers. Cartilage… read more here.

Keywords: mutation mitochondrial; cartilage hair; hypoplasia syndrome; rna processing ... See more keywords

Lexis and Grammar of Mitochondrial RNA Processing in Trypanosomes.

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recommendations! Published in 2020 at "Trends in parasitology"

DOI: 10.1016/j.pt.2020.01.006

Abstract: Trypanosoma brucei spp. cause African human and animal trypanosomiasis, a burden on health and economy in Africa. These hemoflagellates are distinguished by a kinetoplast nucleoid containing mitochondrial DNAs of two kinds: maxicircles encoding ribosomal RNAs… read more here.

Keywords: grammar mitochondrial; rna; lexis grammar; rna processing ... See more keywords
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The roles of RNA processing in translating genotype to phenotype

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recommendations! Published in 2017 at "Nature Reviews Molecular Cell Biology"

DOI: 10.1038/nrm.2016.139

Abstract: A goal of human genetics studies is to determine the mechanisms by which genetic variation produces phenotypic differences that affect human health. Efforts in this respect have previously focused on genetic variants that affect mRNA… read more here.

Keywords: processing translating; variants affect; genotype phenotype; translating genotype ... See more keywords

Noncoding RNA processing by DIS3 regulates chromosomal architecture and somatic hypermutation in B cells

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recommendations! Published in 2021 at "Nature Genetics"

DOI: 10.1038/s41588-020-00772-0

Abstract: Noncoding RNAs are exquisitely titrated by the cellular RNA surveillance machinery for regulating diverse biological processes. The RNA exosome, the predominant 3′ RNA exoribonuclease in mammalian cells, is composed of nine core and two catalytic… read more here.

Keywords: noncoding rna; rna; rna processing; dis3 ... See more keywords