Action and function of helicases on RNA G-quadruplexes.
Sign Up to like & getrecommendations! Published in 2021 at "Methods"
DOI: 10.1016/j.ymeth.2021.09.003
Abstract: The nucleic acid structure called G-quadruplex (G4) is currently discussed to function in nucleic acid-based mechanisms that influence several cellular processes. They can modulate the cellular machinery either positively or negatively, both at the DNA… read more here.
Keywords: rna quadruplexes; helicases rna; action function; biology ... See more keywords
RNA G-Quadruplexes in Kirsten Ras (KRAS) Oncogene as Targets for Small Molecules Inhibiting Translation.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.7b00622
Abstract: The human KRAS transcript contains a G-rich 5'-UTR sequence (77% GC) harboring several G4 motifs capable to form stable RNA G-quadruplex (RG4) structures that can serve as targets for small molecules. A biotin-streptavidin pull-down assay… read more here.
Keywords: rna quadruplexes; targets small; small molecules; kras oncogene ... See more keywords
RNA G-quadruplexes (rG4s): genomics and biological functions
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab187
Abstract: Abstract G-quadruplexes (G4s) are non-classical DNA or RNA secondary structures that have been first observed decades ago. Over the years, these four-stranded structural motifs have been demonstrated to have significant regulatory roles in diverse biological… read more here.
Keywords: rna quadruplexes; biological functions; rg4s genomics; quadruplexes rg4s ... See more keywords
A high-throughput screen identifies small molecule modulators of alternative splicing by targeting RNA G-quadruplexes
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz036
Abstract: Abstract RNA secondary structures have been increasingly recognized to play an important regulatory role in post-transcriptional gene regulation. We recently showed that RNA G-quadruplexes, which serve as cis-elements to recruit splicing factors, play a critical… read more here.
Keywords: throughput screen; alternative splicing; rna quadruplexes; high throughput ... See more keywords
Targeting RNA Gâquadruplexes as new treatment strategy for C9orf72 ALS/FTD
Sign Up to like & getrecommendations! Published in 2018 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.201708572
Abstract: The recent discovery of a pathogenic expansion of a (GGGGCC)n repeat in the C9orf72 gene in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) led to a burst of mechanistic discoveries. In this issue, Simone… read more here.
Keywords: targeting rna; rna quadruplexes; strategy c9orf72; treatment strategy ... See more keywords
Tracking Topological and Electronic Effects on the Folding and Stability of Guanine-Deficient RNA G-Quadruplexes, Engineered with a New Computational Tool for De Novo Quadruplex Folding
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231910990
Abstract: The initial aim of this work was to elucidate the mutual influence of different single-stranded segments (loops and caps) on the thermodynamic stability of RNA G-quadruplexes. To this end, we used a new NAB-GQ-builder software… read more here.
Keywords: tracking topological; rna quadruplexes; quadruplex folding; stability ... See more keywords