The Transactions of NS3 and NS5 in Flaviviral RNA Replication.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-10-8727-1_11
Abstract: Dengue virus (DENV) replication occurs in virus-induced vesicles that contain the replication complex (RC) where viral RNA, viral proteins and host proteins participate in RNA-RNA, RNA-protein and protein-protein interactions to ensure viral genome synthesis. However,… read more here.
Keywords: protein; rna replication; rna; ns3 ns5 ... See more keywords
A Potential Role for Aminoacylation in Primordial RNA Copying Chemistry.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry"
DOI: 10.1021/acs.biochem.0c00943
Abstract: Aminoacylated tRNAs are the substrates for ribosomal protein synthesis in all branches of life, implying an ancient origin for aminoacylation chemistry. In the 1970s, Orgel and colleagues reported potentially prebiotic routes to aminoacylated nucleotides and… read more here.
Keywords: rna replication; chemistry; role aminoacylation; aminoacylation ... See more keywords
Membrane Topology of Pestiviral Nonstructural Protein 2 and Determination of the Minimal Autoprotease Domain
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Virology"
DOI: 10.1128/jvi.00154-21
Abstract: Pestiviral NS2 is central to the regulation of RNA replication and virion morphogenesis via its autoprotease activity. This activity is temporally regulated by the cellular chaperone DNAJC14 as a cofactor: while free NS3 is required… read more here.
Keywords: morphogenesis; pestiviral ns2; rna replication; topology ... See more keywords
Model System for the Formation of Tick-Borne Encephalitis Virus Replication Compartments without Viral RNA Replication
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Virology"
DOI: 10.1128/jvi.00292-19
Abstract: TBEV infection causes a broad spectrum of symptoms, ranging from mild fever to severe encephalitis. Similar to other flaviviruses, TBEV exploits intracellular membranes to build RCs for viral replication. The viral NS proteins have been… read more here.
Keywords: system; formation; replication; rna replication ... See more keywords
G3BP/Rin-Binding Motifs Inserted into Flexible Regions of nsP2 Support RNA Replication of Chikungunya Virus
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.01278-22
Abstract: CHIKV is a reemerging alphavirus that has spread throughout more than 60 countries and is the causative agent of chikungunya fever. No approved drugs or vaccines are available for the treatment or prevention of CHIKV… read more here.
Keywords: replication; binding motifs; g3bp rin; rna replication ... See more keywords
CRISPR/Cas9-Mediated Knockout of DNAJC14 Verifies This Chaperone as a Pivotal Host Factor for RNA Replication of Pestiviruses
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Virology"
DOI: 10.1128/jvi.01714-18
Abstract: Only noncp pestivirus strains are capable of establishing life-long persistent infections to generate the virus reservoir in the field. The molecular basis for this biotype is only partially understood and only investigated in depth for… read more here.
Keywords: rna replication; noncp; biotype; dnajc14 ... See more keywords
IFITM1 enhances nonenveloped viral RNA replication by facilitating cholesterol transport to the Golgi.
Sign Up to like & getrecommendations! Published in 2023 at "PLoS pathogens"
DOI: 10.1371/journal.ppat.1011383
Abstract: Aichi virus (AiV), a small non-enveloped RNA virus, hijacks the endoplasmic reticulum (ER)–Golgi cholesterol transport machinery to form cholesterol-rich replication sites originating from Golgi membranes. Interferon-induced transmembrane proteins (IFITMs) are antiviral restriction factors, whose involvement… read more here.
Keywords: cholesterol transport; replication; rna replication; golgi ... See more keywords
SNAP23 is essential for germination of EV-D68 replication organelles.
Sign Up to like & getrecommendations! Published in 2022 at "Virology"
DOI: 10.2139/ssrn.4226394
Abstract: Picornaviruses rearrange host cell membranes to facilitate their own replication. Here we investigate the Qbc SNARE, SNAP23, which is found at the plasma membrane and plays roles in exocytosis. We found that knockdown of SNAP23… read more here.
Keywords: replication organelles; replication; snap23 essential; rna replication ... See more keywords
Hepatitis C Viral Replication Complex
Sign Up to like & getrecommendations! Published in 2021 at "Viruses"
DOI: 10.3390/v13030520
Abstract: The life cycle of the hepatitis C virus (HCV) can be divided into several stages, including viral entry, protein translation, RNA replication, viral assembly, and release. HCV genomic RNA replication occurs in the replication organelles… read more here.
Keywords: rna replication; hcv genomic; genomic rna; replication complex ... See more keywords
Expression of Alphavirus Nonstructural Protein 2 (nsP2) in Mosquito Cells Inhibits Viral RNA Replication in Both a Protease Activity-Dependent and -Independent Manner
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14061327
Abstract: Alphaviruses are positive-strand RNA viruses, mostly being mosquito-transmitted. Cells infected by an alphavirus become resistant to superinfection due to a block that occurs at the level of RNA replication. Alphavirus replication proteins, called nsP1-4, are… read more here.
Keywords: rna; rna replication; protease activity; activity ... See more keywords
Multifunctional Protein A Is the Only Viral Protein Required for Nodavirus RNA Replication Crown Formation
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14122711
Abstract: Positive-strand RNA virus RNA genome replication occurs in membrane-associated RNA replication complexes (RCs). Nodavirus RCs are outer mitochondrial membrane invaginations whose necked openings to the cytosol are “crowned” by a 12-fold symmetrical proteinaceous ring that… read more here.
Keywords: replication; rna replication; viral protein; formation ... See more keywords