Evolution of RNA sensing receptors in birds
Sign Up to like & getrecommendations! Published in 2022 at "Immunogenetics"
DOI: 10.1007/s00251-021-01238-1
Abstract: Birds are important hosts for many RNA viruses, including influenza A virus, Newcastle disease virus, West Nile virus and coronaviruses. Innate defense against RNA viruses in birds involves detection of viral RNA by pattern recognition… read more here.
Keywords: sensing receptors; evolution rna; birds receptors; virus ... See more keywords
Intracellular RNA Sensing in Mammalian Cells: Role in Stress Response and Cancer Therapies.
Sign Up to like & getrecommendations! Published in 2019 at "International review of cell and molecular biology"
DOI: 10.1016/bs.ircmb.2018.08.005
Abstract: DNA damage has been considered the primary action of ionizing radiation (IR) in normal and tumor cells resulting in cell autonomous death. However, recent findings have elucidated novel local and systemic effects of IR mediated… read more here.
Keywords: rna sensing; response; rna; stress ... See more keywords
FIT-PNAs as RNA-Sensing Probes for Drug-Resistant Plasmodium falciparum.
Sign Up to like & getrecommendations! Published in 2022 at "ACS sensors"
DOI: 10.1021/acssensors.1c01481
Abstract: Detecting RNA at single-nucleotide resolution is a formidable task. Plasmodium falciparum is the deadliest form of malaria in humans and has shown to gain resistance to essentially all antimalarial drugs including artemisinin and chloroquine. Some… read more here.
Keywords: plasmodium falciparum; fit pnas; drug; rna sensing ... See more keywords
Smartphone DNA or RNA-Sensing Using Semisynthetic Luciferase-Based Logic Device.
Sign Up to like & getrecommendations! Published in 2020 at "ACS sensors"
DOI: 10.1021/acssensors.9b02454
Abstract: Detection of specific oligonucleotide sequences is central to numerous applications and technologies amenable to point-of-care diagnostics or end users are needed. Here we report a technology making use of a biolumi-nescent readout and smartphone quantification.… read more here.
Keywords: sensing using; rna sensing; semisynthetic luciferase; smartphone dna ... See more keywords
Host cytosolic RNA sensing pathway promotes T Lymphocyte-mediated mycobacterial killing in macrophages
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1008569
Abstract: Mycobacterial infection leads to activation of the RIG-I/MAVS/TBK1 RNA sensing pathway in macrophages but the consequences of this activation remains poorly defined. In this study, we determined that activation of this RNA sensing pathway stimulates… read more here.
Keywords: sensing pathway; mediated mycobacterial; rna sensing; lymphocyte mediated ... See more keywords
ADAR1 RNA editing regulates endothelial cell functions via the MDA-5 RNA sensing signaling pathway
Sign Up to like & getrecommendations! Published in 2021 at "Life Science Alliance"
DOI: 10.26508/lsa.202101191
Abstract: Cellular RNA transcripts in endothelial cells, especially the SINE RNAs, need extensive editing by the A-to-I RNA editing enzyme ADAR1, which is essential for neonatal survival by regulating the MDA-5–mediated RNA-sensing signaling pathway. The RNA-sensing… read more here.
Keywords: rna editing; sensing signaling; signaling pathway; mda ... See more keywords