Mapping the Conformational Landscape of the Neutral Network of RNA Sequences That Connect Two Functional Distinctly Different Ribozymes
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200022
Abstract: During evolution of an RNA world, the development of enzymatic function was essential. Such enzymatic function was linked to RNA sequences capable of adopting specific RNA folds that possess catalytic pockets to promote catalysis. Within… read more here.
Keywords: rna sequences; neutral network; ribozyme; rna ... See more keywords
Cloning and characterization of Bubaline mammary miRNAs: An in silico approach
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology Reports"
DOI: 10.1007/s11033-019-04594-0
Abstract: MicroRNAs (miRNAs) are small non-coding RNAs ~ 19–25 nucleotides long that are involved in the regulation of gene expression. They negatively regulate the gene expression via inhibition or complete degradation of mRNAs by binding the complementary… read more here.
Keywords: bubaline mammary; small rna; rna sequences; bubaline small ... See more keywords
Stability of RNA sequences derived from the coronavirus genome in human cells
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and Biophysical Research Communications"
DOI: 10.1016/j.bbrc.2020.05.008
Abstract: Abstract Most viruses inhibit the innate immune system and/or the RNA degradation processes of host cells to construct an advantageous intracellular environment for their survival. Characteristic RNA sequences within RNA virus genomes or RNAs transcribed… read more here.
Keywords: sequences derived; stability rna; rna; rna sequences ... See more keywords
iMethyl-STTNC: Identification of N6-methyladenosine sites by extending the idea of SAAC into Chou's PseAAC to formulate RNA sequences.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2018.07.018
Abstract: N6- methyladenosine (m6A) is a vital post-transcriptional modification, which adds another layer of epigenetic regulation at RNA level. It chemically modifies mRNA that effects protein expression. RNA sequence contains many genetic code motifs (GAC). Among… read more here.
Keywords: rna; methyladenosine; model; rna sequences ... See more keywords
Nitrogen-doped porous carbon-based fluorescence sensor for the detection of ZIKV RNA sequences: fluorescence image analysis.
Sign Up to like & getrecommendations! Published in 2019 at "Talanta"
DOI: 10.1016/j.talanta.2019.06.091
Abstract: Many studies have demonstrated that metal-organic frameworks (MOFs) are universal fluorescence quenchers for DNA/RNA detection. Nevertheless, the structural stability of many MOFs is relatively weak, which limits their practical applications. Thus, it remains a great… read more here.
Keywords: rna sequences; zikv rna; fluorescence; rna ... See more keywords
TOPAS: network-based structural alignment of RNA sequences
Sign Up to like & getrecommendations! Published in 2019 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btz001
Abstract: Motivation For many RNA families, the secondary structure is known to be better conserved among the member RNAs compared to the primary sequence. For this reason, it is important to consider the underlying folding structures… read more here.
Keywords: network based; structural alignment; topas; alignment ... See more keywords
QRNAstruct: a method for extracting secondary structural features of RNA via regression with biological activity
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac220
Abstract: Abstract Recent technological advances have enabled the generation of large amounts of data consisting of RNA sequences and their functional activity. Here, we propose a method for extracting secondary structure features that affect the functional… read more here.
Keywords: rna sequences; extracting secondary; method extracting; activity ... See more keywords
Tagging and Capturing of Lentiviral Vectors Using Short RNAs
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DOI: 10.3390/ijms221910263
Abstract: Lentiviral (LV) vectors have emerged as powerful tools for transgene delivery ex vivo but in vivo gene therapy applications involving LV vectors have faced a number of challenges, including the low efficiency of transgene delivery,… read more here.
Keywords: vector; rna; lentiviral vectors; tagging capturing ... See more keywords
4D-Dynamic Representation of DNA/RNA Sequences: Studies on Genetic Diversity of Echinococcus multilocularis in Red Foxes in Poland
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DOI: 10.3390/life12060877
Abstract: The 4D-Dynamic Representation of DNA/RNA Sequences, an alignment-free bioinformatics method recently developed by us, has been used to study the genetic diversity of Echinococcus multilocularis in red foxes in Poland. Sequences of three mitochondrial genes,… read more here.
Keywords: rna sequences; dynamic representation; representation dna; genetic diversity ... See more keywords