Small RNA sequencing in hypoxic naked mole‐rat hearts suggests microRNA regulation of RNA‐ and translation‐related processes
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14499
Abstract: The naked mole‐rat (Heterocephalus glaber) regularly endures intermittent periods of hypoxia in its burrows, surviving in part due to metabolic rate depression (MRD)—a strategy of conserving cellular resources by downregulating nonessential gene expression and reorganizing cellular… read more here.
Keywords: rna sequencing; naked mole; translation related; small rna ... See more keywords
Imaging phenotypes from MRI for the prediction of glioma immune subtypes from RNA sequencing: A multicenter study
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13380
Abstract: Tumor subtyping based on its immune landscape may guide precision immunotherapy. The aims of this study were to identify immune subtypes of adult diffuse gliomas with RNA sequencing data, and to noninvasively predict this subtype… read more here.
Keywords: rna sequencing; immune subtypes; radiomic signature; subtype ... See more keywords
Single‐Nucleus RNA Sequencing and Spatial Transcriptomics Reveal the Immunological Microenvironment of Cervical Squamous Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202203040
Abstract: Effective treatment of advanced invasive cervical cancer remains challenging nowadays. Herein, single-nucleus RNA sequencing (snRNA-seq) and SpaTial Enhanced REsolution Omics-sequencing (Stereo-seq) technology are used to investigate the immunological microenvironment of cervical squamous cell carcinoma (CSCC),… read more here.
Keywords: immunological microenvironment; rna sequencing; microenvironment; single nucleus ... See more keywords
Single cell RNA‐sequencing: A powerful yet still challenging technology to study cellular heterogeneity
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200084
Abstract: Almost all biomedical research to date has relied upon mean measurements from cell populations, however it is well established that what it is observed at this macroscopic level can be the result of many interactions… read more here.
Keywords: cell; heterogeneity; rna sequencing; single cell ... See more keywords
RNA sequencing of myeloid sarcoma, shed light on myeloid sarcoma stratification
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Medicine"
DOI: 10.1002/cam4.5654
Abstract: Myeloid sarcoma (MS) is a rare, extramedullary tumor consisting of myeloid blasts. Little is known about the genetic background of MS and the prognostic value of genetic abnormalities in MS. In particular, the broad variety… read more here.
Keywords: myeloid sarcoma; rna sequencing; sarcoma; sequencing myeloid ... See more keywords
RNA sequencing and expression heterogeneity in head and neck cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Cytopathology"
DOI: 10.1002/cncy.22622
Abstract: The annual incidence of head and neck squamous cell carcinoma (HNSCC) is approximately 600,000 cases worldwide and 60,000 cases in the United States; HNSCC accounts for 3% of cancers nationally. Despite advances in surgical techniques… read more here.
Keywords: cell; rna sequencing; head neck; expression ... See more keywords
Assessment of stained direct cytology smears of breast cancer for whole transcriptome and targeted messenger RNA sequencing
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Cytopathology"
DOI: 10.1002/cncy.22679
Abstract: Rather than surgical resection, cytologic specimens are often used as first‐line clinical diagnostic procedures due to higher safety, speed, and cost‐effectiveness. Archival diagnostic cytology slides containing cancer can be equivalent to tissue biopsies for DNA… read more here.
Keywords: assessment stained; rna sequencing; stained direct; cytology ... See more keywords
Large-scale single cell RNA sequencing atlases of human immune cells across lifespan: possibilities and challenges.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202250222
Abstract: Single cell RNA sequencing technologies have been successfully leveraged for immunological insights into human prenatal, paediatric and adult tissues. These single cell studies have led to breakthroughs in our understanding of stem, myeloid and lymphoid… read more here.
Keywords: cell; rna sequencing; large scale; single cell ... See more keywords
Targeted RNA sequencing: A routine ancillary technique in the diagnosis of bone and soft tissue neoplasms
Sign Up to like & getrecommendations! Published in 2019 at "Genes"
DOI: 10.1002/gcc.22690
Abstract: The past decade has witnessed remarkable progress in delineating the molecular pathogenesis of many mesenchymal neoplasms. This, in large part, is attributable to the application of next‐generation sequencing. As these techniques decrease in cost, and… read more here.
Keywords: soft tissue; bone soft; tissue; rna sequencing ... See more keywords
Gene fusion analysis in renal cell carcinoma by FusionPlex RNA‐sequencing and correlations of molecular findings with clinicopathological features
Sign Up to like & getrecommendations! Published in 2019 at "Genes"
DOI: 10.1002/gcc.22798
Abstract: Translocation renal cell carcinoma (tRCC) affects younger patients and often presents as advanced disease. Accurate diagnosis is required to guide clinical management. Here we evaluate the RNA‐sequencing FusionPlex platform with a 115‐gene panel including TFE3… read more here.
Keywords: tfe3; analysis; rna sequencing; fusion ... See more keywords
Deep intronic NIPBL de novo mutations and differential diagnoses revealed by whole genome and RNA sequencing in Cornelia de Lange syndrome patients
Sign Up to like & getrecommendations! Published in 2022 at "Human Mutation"
DOI: 10.1002/humu.24438
Abstract: Cornelia de Lange syndrome (CdLS; MIM# 122470) is a rare developmental disorder. Pathogenic variants in 5 genes explain approximately 50% cases, leaving the other 50% unsolved. We performed whole genome sequencing (WGS) ± RNA sequencing (RNA‐seq) in… read more here.
Keywords: lange syndrome; rna sequencing; deep intronic; rna ... See more keywords