NMR characterization of RNA small molecule interactions.
Sign Up to like & getrecommendations! Published in 2019 at "Methods"
DOI: 10.1016/j.ymeth.2019.05.015
Abstract: Exciting discoveries of naturally occurring ligand-sensing and disease-linked noncoding RNAs have promoted significant interests in understanding RNA-small molecule interactions. NMR spectroscopy is a powerful tool for characterizing intermolecular interactions. In this review, we describe protocols… read more here.
Keywords: small molecule; rna small; spectroscopy; molecule interactions ... See more keywords
Fluorescence-based investigations of RNA-small molecule interactions.
Sign Up to like & getrecommendations! Published in 2019 at "Methods"
DOI: 10.1016/j.ymeth.2019.05.017
Abstract: Interrogating non-coding RNA structures and functions with small molecules is an area of rapidly increasing interest among biochemists and chemical biologists. However, many biochemical approaches to monitoring RNA structures are time-consuming and low-throughput, and thereby… read more here.
Keywords: molecule; fluorescence based; small molecule; rna small ... See more keywords
Strategies for targeting RNA with small molecule drugs
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2022.2111414
Abstract: ABSTRACT Introduction Historically, therapeutic treatment of disease has been restricted to targeting proteins. Of the approximately 20,000 translated human proteins, approximately 1600 are associated with diseases. Strikingly, less than 15% of disease-associated proteins are predicted… read more here.
Keywords: small molecule; targeting rna; molecule; molecule drugs ... See more keywords
Long non-coding RNA-small nucleolar RNA host gene 7 regulates inflammatory responses following spinal cord injury by regulating the microRNA-449a/TNF-α-induced protein 3-interacting protein 2 axis
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2061294
Abstract: ABSTRACT The current study aimed to explore the anti-inflammatory effects of long non-coding RNA-small nucleolar RNA host gene 7 (lncRNA-SNHG7) and its mechanism in spinal cord injury (SCI) models. SCI models were established both in… read more here.
Keywords: long non; lncrna snhg7; rna small; injury ... See more keywords
Augmented base pairing networks encode RNA-small molecule binding preferences
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa583
Abstract: Abstract RNA-small molecule binding is a key regulatory mechanism which can stabilize 3D structures and activate molecular functions. The discovery of RNA-targeting compounds is thus a current topic of interest for novel therapies. Our work… read more here.
Keywords: base pairing; small molecule; molecule binding; rna small ... See more keywords
dSPRINT: predicting DNA, RNA, ion, peptide and small molecule interaction sites within protein domains
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab356
Abstract: Abstract Domains are instrumental in facilitating protein interactions with DNA, RNA, small molecules, ions and peptides. Identifying ligand-binding domains within sequences is a critical step in protein function annotation, and the ligand-binding properties of proteins… read more here.
Keywords: protein; ligand binding; protein domains; dna rna ... See more keywords
Targeting RNA with small molecules a safety perspective.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of pharmacology"
DOI: 10.1111/bph.16027
Abstract: RNA is a major player in cellular function and consequently can drive a number of disease pathologies. Over the past several years, small molecule-RNA targeting (smRNA) has developed into a promising drug discovery approach. Numerous… read more here.
Keywords: safety; targeting rna; rna; rna small ... See more keywords
Assessing the feasibility and stability of uracil base flipping in RNA–small molecule complexes using molecular dynamics simulations
Sign Up to like & getrecommendations! Published in 2020 at "Canadian Journal of Chemistry"
DOI: 10.1139/cjc-2019-0421
Abstract: Small molecules can be used to target RNAs that mediate disease. A fundamental understanding of binding interactions between RNA and small molecules and the structure of their complexes will furthe... read more here.
Keywords: feasibility stability; uracil base; base flipping; rna small ... See more keywords
Targeting RNA with small molecules: lessons learned from Xist RNA
Sign Up to like & getrecommendations! Published in 2023 at "RNA"
DOI: 10.1261/rna.079523.122
Abstract: Although more than 98% of the human genome is noncoding, nearly all drugs on the market target one of about 700 disease-related proteins. However, an increasing number of diseases are now being attributed to noncoding… read more here.
Keywords: rna targeting; targeting rna; lessons learned; rna ... See more keywords