Splicing and neurodegeneration: Insights and mechanisms
Sign Up to like & getrecommendations! Published in 2019 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1532
Abstract: Splicing is the global cellular process whereby intervening sequences (introns) in precursor messenger RNA (pre‐mRNA) are removed and expressed regions (exons) are ligated together, resulting in a mature mRNA transcript that is exported and translated… read more here.
Keywords: splicing neurodegeneration; neurodegeneration insights; neurodegeneration; insights mechanisms ... See more keywords
Alternative splicing in aging and longevity
Sign Up to like & getrecommendations! Published in 2019 at "Human Genetics"
DOI: 10.1007/s00439-019-02094-6
Abstract: Alternative pre-mRNA splicing increases the complexity of the proteome that can be generated from the available genomic coding sequences. Dysregulation of the splicing process has been implicated in a vast repertoire of diseases. However, splicing… read more here.
Keywords: longevity; splicing aging; aging longevity; rna splicing ... See more keywords
Single Molecules in Focus: From RNA Splicing to Silencing
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.054
Abstract: Nature and Nanotechnology likewise employ nanoscale machines that self-assemble into structures of complex architecture and functionality. Fluorescence microscopy offers a non-invasive tool to probe and ultimately dissect and control these nanoassemblies in real-time. In particular,… read more here.
Keywords: molecule; single molecule; single molecules; molecules focus ... See more keywords
NMR Studies of Conformational Selection of hnRNP H on RNA Splicing
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1877
Abstract: Modularity provides proteins versatility in regulating many cellular processes. The RNA Recognition Motif (RRM) is a common protein family that adopts modularity to facilitate its biological activity. hnRNP H contains three RRMs that play important… read more here.
Keywords: conformational selection; hnrnp; form; closed form ... See more keywords
Mutations of RNA splicing factors in hematological malignancies.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2017.08.042
Abstract: Systematic large-scale cancer genomic studies have produced numerous significant findings. These studies have not only revealed new cancer-promoting genes, but they also have identified cancer-promoting functions of previously known "housekeeping" genes. These studies have identified… read more here.
Keywords: mutations rna; cancer; factors hematological; rna splicing ... See more keywords
Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer cell"
DOI: 10.1016/j.ccell.2020.05.010
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is driven by co-existing mutations in KRAS and TP53. However, how these mutations collaborate to promote this cancer is unknown. Here, we uncover sequence-specific changes in RNA splicing enforced by mutant… read more here.
Keywords: altered rna; splicing mutant; mutant p53; cancer ... See more keywords
Methylmercury exposure alters RNA splicing in human neuroblastoma SK-N-SH cells: Implications from proteomic and post-transcriptional responses.
Sign Up to like & getrecommendations! Published in 2018 at "Environmental pollution"
DOI: 10.1016/j.envpol.2018.03.019
Abstract: The neurotoxic effects of methylmercury (MeHg) have been intensively studied. However, the molecular mechanisms responsible for the neurotoxicity of MeHg are not fully understood. To decipher these mechanisms, proteomic and high-throughput mRNA sequencing (RNA-seq) technique… read more here.
Keywords: exposure; human neuroblastoma; mehg exposure; rna splicing ... See more keywords
Developing ABEmax-NG with Precise Targeting and Expanded Editing Scope to Model Pathogenic Splice Site Mutations In Vivo
Sign Up to like & getrecommendations! Published in 2019 at "iScience"
DOI: 10.1016/j.isci.2019.05.008
Abstract: Summary RNA splicing is related to many human diseases; however, lack of efficient genetic approaches to modulate splicing has prevented us from dissecting their functions in human diseases. Recently developed base editors (BEs) offer a… read more here.
Keywords: splice; developing abemax; scope; abemax precise ... See more keywords
Therapeutic Modulation of RNA Splicing in Malignant and Non-Malignant Disease.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in molecular medicine"
DOI: 10.1016/j.molmed.2021.04.005
Abstract: RNA splicing is the enzymatic process by which non-protein coding sequences are removed from RNA to produce mature protein-coding mRNA. Splicing is thereby a major mediator of proteome diversity as well as a dynamic regulator… read more here.
Keywords: splicing malignant; non; rna; therapeutic modulation ... See more keywords
IQGAP1 and RNA Splicing in the Context of Head and Neck via Phosphoproteomics.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.2c00309
Abstract: IQGAP1 (IQ motif-containing GTPase-activating protein 1) scaffolds several signaling pathways in mammalian cells that are implicated in carcinogenesis, including the RAS and PI3K pathways that involve multiple protein kinases. IQGAP1 has been shown to promote… read more here.
Keywords: head neck; rna splicing; iqgap1 rna; iqgap1 ... See more keywords
Human DBR1 modulates the recycling of snRNPs to affect alternative RNA splicing and contributes to the suppression of cancer development
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2017.150
Abstract: The contribution of RNA processing to tumorigenesis is understudied. Here, we report that the human RNA debranching enzyme (hDBR1), when inappropriately regulated, induces oncogenesis by causing RNA processing defects, for example, splicing defects. We found… read more here.
Keywords: hdbr1; human dbr1; rna; expression ... See more keywords