Regulation of cytoplasmic RNA stability: Lessons from Drosophila
Sign Up to like & getrecommendations! Published in 2018 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1499
Abstract: The process of RNA degradation is a critical level of regulation contributing to the control of gene expression. In the last two decades a number of studies have shown the specific and targeted nature of… read more here.
Keywords: control; rna stability; stability; regulation cytoplasmic ... See more keywords
Transcriptome-Wide Profiling of RNA Stability.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1851-6_17
Abstract: Gene expression is controlled at multiple levels, including RNA transcription and turnover. But determining the relative contributions of RNA biogenesis and decay to the steady-state abundance of cellular transcripts remains challenging because conventional transcriptomics approaches… read more here.
Keywords: profiling rna; rna stability; transcriptome wide; wide profiling ... See more keywords
Evaluating the Stability of mRNAs and Noncoding RNAs.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-4035-6_11
Abstract: Changes in RNA stability have an important impact in the gene expression regulation. Different methods based on the transcription blockage with RNA polymerase inhibitors or metabolic labeling of newly synthesized RNAs have been developed to… read more here.
Keywords: stability mrnas; rna stability; evaluating stability; noncoding rnas ... See more keywords
Modulation of RNA stability regulates gene expression in two opposite ways: through buffering of RNA levels upon global perturbations and by supporting adapted differential expression
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac208
Abstract: Abstract The steady state levels of RNAs, often referred to as expression levels, result from a well-balanced combination of RNA transcription and decay. Alterations in RNA levels will therefore result from tight regulation of transcription… read more here.
Keywords: gene expression; rna stability; expression;
Low RNA stability signifies increased post-transcriptional regulation of cell identity genes.
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad300
Abstract: Cell identity genes are distinct from other genes with respect to the epigenetic mechanisms to activate their transcription, e.g. by super-enhancers and broad H3K4me3 domains. However, it remains unclear whether their post-transcriptional regulation is also… read more here.
Keywords: cell identity; cell; identity genes; rna stability ... See more keywords
Gene expression regulated by RNA stability
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.aba0713
Abstract: The factor responsible for autoregulation of tubulin RNA stability is identified One of the first discoveries of gene expression mediated by controlling messenger RNA (mRNA) stability is autoregulation of tubulin synthesis. In this regulatory process,… read more here.
Keywords: tubulin; rna stability; stability; gene expression ... See more keywords
PARN Modulates Y RNA Stability and Its 3′-End Formation
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Biology"
DOI: 10.1128/mcb.00264-17
Abstract: ABSTRACT Loss-of-function mutations in 3′-to-5′ exoribonucleases have been implicated in hereditary human diseases. For example, PARN mutations cause a severe form of dyskeratosis congenita (DC), wherein PARN deficiency leads to human telomerase RNA instability. Since… read more here.
Keywords: parn modulates; end; modulates rna; rna stability ... See more keywords
An Evolutionarily Conserved AU-Rich Element in the 3' Untranslated Region of a Transcript Misannotated as a Long Noncoding RNA Regulates RNA Stability
Sign Up to like & getrecommendations! Published in 2022 at "Molecular and Cellular Biology"
DOI: 10.1128/mcb.00505-21
Abstract: One of the primary mechanisms of post-transcriptional gene regulation is the modulation of RNA stability. We recently discovered that LINC00675, a transcript annotated as a long noncoding RNA (lncRNA), is transcriptionally regulated by FOXA1 and… read more here.
Keywords: rna stability; transcript; rna; long noncoding ... See more keywords
Rous Sarcoma Virus RNA Stability Element Inhibits Deadenylation of mRNAs with Long 3′UTRs
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DOI: 10.3390/v9080204
Abstract: All retroviruses use their full-length primary transcript as the major mRNA for Group-specific antigen (Gag) capsid proteins. This results in a long 3′ untranslated region (UTR) downstream of the termination codon. In the case of… read more here.
Keywords: long utrs; rna stability; stability element; sarcoma virus ... See more keywords