CircularSTAR3D: a stack-based RNA 3D structural alignment tool for circular matching
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad222
Abstract: Abstract The functions of non-coding RNAs usually depend on their 3D structures. Therefore, comparing RNA 3D structures is critical in analyzing their functions. We noticed an interesting phenomenon that two non-coding RNAs may share similar… read more here.
Keywords: circular matching; tool; rna structural; circularstar3d ... See more keywords
ConsAlign: simultaneous RNA structural aligner based on rich transfer learning and thermodynamic ensemble model of alignment scoring
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1101/2022.04.27.489566
Abstract: Motivation To capture structural homology in RNAs, predicting RNA structural alignments has been a fundamental framework around RNA science. Learning simultaneous RNA structural alignments in their rich scoring is an undeveloped subject because evaluating them… read more here.
Keywords: simultaneous rna; rna structural; alignment scoring; consalign ... See more keywords
A prometastatic splicing program regulated by SNRPA1 interactions with structured RNA elements
Sign Up to like & getrecommendations! Published in 2021 at "Science"
DOI: 10.1126/science.abc7531
Abstract: Characterizing a cancer spliceosome Cells undergo many genomic changes as they progress toward metastatic cancer. One aspect of this change is to RNA expression and splicing isoforms, but how these differences affect tumor progression is… read more here.
Keywords: rna structural; breast cancer; cancer; snrpa1 ... See more keywords
Aberrant splicing in human cancer: An RNA structural code point of view
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1137154
Abstract: Alternative splicing represents an essential process that occurs widely in eukaryotes. In humans, most genes undergo alternative splicing to ensure transcriptome and proteome diversity reflecting their functional complexity. Over the last decade, aberrantly spliced transcripts… read more here.
Keywords: rna structural; aberrant splicing; splicing human; human cancer ... See more keywords