A RNA-targeted Two-photon Bio-probe with High Selective Permeability into Nuclear Pore Complexes for Dynamically Tracking the Autophagy Process among Multi-Organelles.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.9b03009
Abstract: Dynamic tracking of the spatiotemporal coordination among various organelles to in-depth understanding of the mechanism of autophagy have attracted considerable attentions. However, the monitor of nucleoli participation in autophagy was somehow neglected. Herein, we report… read more here.
Keywords: autophagy process; high selective; multi organelles; bio probe ... See more keywords
R-BIND: An Interactive Database for Exploring and Developing RNA-Targeted Chemical Probes.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical biology"
DOI: 10.1021/acschembio.9b00631
Abstract: While the opportunities available for targeting RNA with small molecules have been widely appreciated, the challenges associated with achieving specific RNA recognition in biological systems have hindered progress and prevented many researchers from entering the… read more here.
Keywords: targeted chemical; exploring developing; rna; database ... See more keywords
Antitumoral RNA‐targeted oligonucleotide therapeutics: The third pillar after small molecule inhibitors and antibodies
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15461
Abstract: Oligonucleotide therapeutics, drugs consisting of 10–50 nucleotide‐long single‐ or double‐stranded DNA or RNA molecules that can bind to specific DNA or RNA sequences or proteins, include antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), microRNAs (miRNAs),… read more here.
Keywords: antitumoral rna; third pillar; rna; targeted oligonucleotide ... See more keywords
RNA-Targeted Therapies and Amyotrophic Lateral Sclerosis
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DOI: 10.3390/biomedicines6010009
Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal motor disease in adults. Its pathophysiology remains mysterious, but tremendous advances have been made with the discovery of the most frequent mutations of its more common familial form… read more here.
Keywords: rna; amyotrophic lateral; rna targeted; targeted therapies ... See more keywords
RNA-Targeted Therapies and High-Throughput Screening Methods
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21082996
Abstract: RNA-binding proteins (RBPs) are involved in regulating all aspects of RNA metabolism, including processing, transport, translation, and degradation. Dysregulation of RNA metabolism is linked to a plethora of diseases, such as cancer, neurodegenerative diseases, and… read more here.
Keywords: medicine; rna; throughput screening; rna targeted ... See more keywords