Decoding the Mechanism of Specific RNA Targeting by Ribosomal Methyltransferases.
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DOI: 10.1021/acschembio.1c00732
Abstract: Methylation of specific nucleotides is integral for ribosomal biogenesis and also serves as a common mechanism to confer antibiotic resistance by pathogenic bacteria. Here, by determining the high-resolution structure of the 30S-KsgA complex by cryo-electron… read more here.
Keywords: specific rna; rna targeting; mechanism specific; decoding mechanism ... See more keywords
Potential Novel RNA-Targeting Agents for Effective Lipoprotein(a) Lowering: A Systematic Assessment of the Evidence from Completed and Ongoing Developmental Clinical Trials.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cardiovascular pharmacology"
DOI: 10.1097/fjc.0000000000001429
Abstract: ABSTRACT An increase in blood lipoprotein (a) [Lp(a)] levels, mostly genetically determined, has been identified as an independent risk factor for atherosclerotic cardiovascular disease. No drug has yet been approved that markedly lowers Lp(a) and… read more here.
Keywords: potential novel; rna targeting; clinical trials; lipoprotein ... See more keywords
Shutting down RNA-targeting CRISPR
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.abc8243
Abstract: The discovery of an anti-CRISPR reveals viral escape from CRISPR immunity Explorations of the evolutionary arms race between bacteria and bacteriophages (viruses that infect bacteria) have unearthed a variety of defense mechanisms that include CRISPR-Cas… read more here.
Keywords: crispr; shutting rna; targeting crispr; rna targeting ... See more keywords
Optimized RNA-targeting CRISPR/Cas13d technology outperforms shRNA in identifying functional circRNAs
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DOI: 10.1186/s13059-021-02263-9
Abstract: Short hairpin RNAs (shRNAs) are used to deplete circRNAs by targeting back-splicing junction (BSJ) sites. However, frequent discrepancies exist between shRNA-mediated circRNA knockdown and the corresponding biological effect, querying their robustness. By leveraging CRISPR/Cas13d tool… read more here.
Keywords: functional circrnas; optimized rna; rna targeting; crispr cas13d ... See more keywords
Programmable macromolecule-based RNA-targeting therapies to treat human neurological disorders
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DOI: 10.1261/rna.079519.122
Abstract: Disruptions in RNA processing play critical roles in the pathogenesis of neurological diseases. In this Perspective, we discuss recent progress in the development of RNA-targeting therapeutic modalities. We focus on progress, limitations, and opportunities in… read more here.
Keywords: rna targeting; programmable macromolecule; neurological disorders; human neurological ... See more keywords
Targeting RNA with small molecules: lessons learned from Xist RNA
Sign Up to like & getrecommendations! Published in 2023 at "RNA"
DOI: 10.1261/rna.079523.122
Abstract: Although more than 98% of the human genome is noncoding, nearly all drugs on the market target one of about 700 disease-related proteins. However, an increasing number of diseases are now being attributed to noncoding… read more here.
Keywords: rna targeting; targeting rna; lessons learned; rna ... See more keywords
RNA-Targeting CRISPR–Cas Systems and Their Applications
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21031122
Abstract: Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)–CRISPR-associated (Cas) systems have revolutionized modern molecular biology. Numerous types of these systems have been discovered to date. Many CRISPR–Cas systems have been used as a backbone for the… read more here.
Keywords: crispr cas; cas; cas systems; targeting crispr ... See more keywords