Targeted lipid nanoparticles for RNA therapeutics and immunomodulation in leukocytes.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced drug delivery reviews"
DOI: 10.1016/j.addr.2020.04.002
Abstract: Abnormalities in leukocytes' function are associated with many immune related disorders, such as cancer, autoimmunity and susceptibility to infectious diseases. Recent developments in Genome-wide-association-studies give rise to new opportunities for novel therapeutics. RNA-based modalities, that… read more here.
Keywords: targeted lipid; nanoparticles rna; rna therapeutics; rna based ... See more keywords
RNA therapeutics for heart disease.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2018.07.037
Abstract: The majority of the human genome encodes non-coding RNAs (ncRNAs), species of RNA without protein-coding potential but with powerful regulatory functions in disease onset and progression. Functional studies demonstrate that both coding and ncRNAs underlie… read more here.
Keywords: heart disease; rna; disease; rna therapeutics ... See more keywords
Biochemical features and mutations of key proteins in SARS-CoV-2 and their impacts on RNA therapeutics
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2021.114424
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic. Three viral proteins, the spike protein (S) for attachment of virus to host cells, 3-chymotrypsin-like cysteine protease (Mpro) for digestion of viral polyproteins… read more here.
Keywords: impacts rna; drug; rna therapeutics; biochemical features ... See more keywords
Tetrahedral Framework Nucleic Acid Delivered RNA Therapeutics Significantly Attenuate Pancreatic Cancer Progression via Inhibition of CTR1-Dependent Copper Absorption.
Sign Up to like & getrecommendations! Published in 2021 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.1c13091
Abstract: Copper is vital for various life processes, whereas severely toxic at excess level. Intracellular copper homeostasis is strictly controlled by a set of transporters and chaperones encoded by the copper homeostasis genes. Increasing evidence has… read more here.
Keywords: copper; pancreatic cancer; rna therapeutics; tetrahedral framework ... See more keywords
Clinical advances of RNA therapeutics for treatment of neurological and neuromuscular diseases
Sign Up to like & getrecommendations! Published in 2022 at "RNA Biology"
DOI: 10.1080/15476286.2022.2066334
Abstract: ABSTRACT RNA therapeutics comprise a diverse group of oligonucleotide-based drugs such as antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), and short hairpin RNAs (shRNAs) that can be designed to selectively interact with drug targets currently… read more here.
Keywords: therapeutics treatment; system; disease; rna therapeutics ... See more keywords
RNA therapeutics for neurological diseases.
Sign Up to like & getrecommendations! Published in 2023 at "British medical bulletin"
DOI: 10.1093/bmb/ldad010
Abstract: INTRODUCTION Ribonucleic acid (RNA) therapeutics are a new class of drugs whose importance is highlighted by the growing number of molecules in the clinic. SOURCES OF DATA We focus on RNA therapeutics for neurogenetic disorders,… read more here.
Keywords: rna therapeutics; therapeutics neurological; neurological diseases;
Small non-coding RNA therapeutics for cardiovascular disease
Sign Up to like & getrecommendations! Published in 2022 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehac463
Abstract: Abstract Novel bio-therapeutic agents that harness the properties of small, non-coding nucleic acids hold great promise for clinical applications. These include antisense oligonucleotides that inhibit messenger RNAs, microRNAs (miRNAs), or long non-coding RNAs; positive effectors… read more here.
Keywords: therapeutics cardiovascular; non coding; disease; rna therapeutics ... See more keywords
A large (scale) advance for small RNA therapeutics
Sign Up to like & getrecommendations! Published in 2018 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aav3895
Abstract: Combining established techniques enables large-scale production of potentially therapeutic extracellular vesicles enriched with specific miRNAs. Combining established techniques enables large-scale production of potentially therapeutic extracellular vesicles enriched with specific miRNAs. read more here.
Keywords: large scale; advance small; small rna; medicine ... See more keywords
RNA therapeutics for improving CAR T cell safety and efficacy.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-2155
Abstract: Autologous chimeric antigen receptor (CAR) T cells have recently emerged as potent tools in the fight against cancer, with promising therapeutic efficacy against haematological malignancies. However, several limitations hamper their widespread clinical use, including availability… read more here.
Keywords: car; rna therapeutics; safety efficacy; car cell ... See more keywords
Endosomal escape of RNA therapeutics: How do we solve this rate-limiting problem?
Sign Up to like & getrecommendations! Published in 2023 at "RNA"
DOI: 10.1261/rna.079507.122
Abstract: With over 15 FDA approved drugs on the market and numerous ongoing clinical trials, RNA therapeutics, such as small interfering RNAs (siRNAs) and antisense oligonucleotides (ASOs), have shown great potential to treat human disease. Their… read more here.
Keywords: problem; rna therapeutics; endosomal escape; rate limiting ... See more keywords
RNA in Therapeutics: CRISPR in the Clinic
Sign Up to like & getrecommendations! Published in 2022 at "Molecules and Cells"
DOI: 10.14348/molcells.2022.0163
Abstract: The advent of the CRISPR-Cas genome editing platform has greatly enhanced the capabilities of researchers in many areas of biology. Its use has also been turned to the development of therapies for genetic diseases and… read more here.
Keywords: therapeutics crispr; rna therapeutics; biology; crispr clinic ... See more keywords