SCISSOR: a framework for identifying structural changes in RNA transcripts
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-020-20593-3
Abstract: High-throughput sequencing protocols such as RNA-seq have made it possible to interrogate the sequence, structure and abundance of RNA transcripts at higher resolution than previous microarray and other molecular techniques. While many computational tools have… read more here.
Keywords: framework; rna seq; changes rna; rna transcripts ... See more keywords
Characterization of the nuclear and cytosolic transcriptomes in human brain tissue reveals new insights into the subcellular distribution of RNA transcripts.
Sign Up to like & getrecommendations! Published in 2021 at "Scientific reports"
DOI: 10.1038/s41598-021-83541-1
Abstract: Transcriptome analysis has mainly relied on analyzing RNA sequencing data from whole cells, overlooking the impact of subcellular RNA localization and its influence on our understanding of gene function, and interpretation of gene expression signatures… read more here.
Keywords: analysis; rna; human brain; rna transcripts ... See more keywords
A journey upstream: Fluctuating platelet-specific genes in cell-free plasma as proof-of-concept for using ribonucleic acid sequencing to improve understanding of postinjury platelet biology
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Trauma and Acute Care Surgery"
DOI: 10.1097/ta.0000000000002681
Abstract: BACKGROUND The mechanisms of aberrant circulating platelet behavior following injury remain unclear. Platelets retain megakaryocyte immature ribonucleic acid (RNA) splicing and protein synthesis machinery to alter their functions based on physiologic signals. We sought to… read more here.
Keywords: platelet specific; biology; rna transcripts; platelet ... See more keywords
Differential Expression of MED12-Associated Coding RNA Transcripts in Uterine Leiomyomas
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24043742
Abstract: Recent studies have demonstrated that somatic MED12 mutations in exon 2 occur at a frequency of up to 80% and have a functional role in leiomyoma pathogenesis. The objective of this study was to elucidate… read more here.
Keywords: rna transcripts; med12 mutations; rna; expression ... See more keywords