Current trends in RNA virus detection through metatranscriptome sequencing data.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS open bio"
DOI: 10.1002/2211-5463.13626
Abstract: With advances in sequencing technology, metatranscriptome sequencing from a variety of environmental and biological sources has revealed the existence of various previously unknown RNA viruses. This review presents recent major RNA virome studies sampled from… read more here.
Keywords: virus detection; current trends; trends rna; rna virus ... See more keywords
FIP200 restricts RNA virus infection by facilitating RIG-I activation
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-02450-1
Abstract: Retinoic acid-inducible gene I (RIG-I) senses viral RNA and instigates an innate immune signaling cascade to induce type I interferon expression. Currently, the regulatory mechanisms controlling RIG-I activation remain to be fully elucidated. Here we… read more here.
Keywords: virus infection; rig activation; rna virus; activation ... See more keywords
An ultrafast one-step assay for the visual detection of RNA virus.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical communications"
DOI: 10.1039/c8cc00150b
Abstract: A one-step, rapid, and visual method was developed for the detection of RNA viruses and a few copies of the Zika RNA virus were directly detected within 25 min by naked-eye observation. This method will… read more here.
Keywords: detection rna; one step; rna virus;
LAMPA, LArge Multidomain Protein Annotator, and its application to RNA virus polyproteins
Sign Up to like & getrecommendations! Published in 2020 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btaa065
Abstract: Abstract Motivation To facilitate accurate estimation of statistical significance of sequence similarity in profile–profile searches, queries should ideally correspond to protein domains. For multidomain proteins, using domains as queries depends on delineation of domain borders,… read more here.
Keywords: protein; statistical significance; lampa large; multidomain ... See more keywords
VirBot: an RNA viral contig detector for metagenomic data
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DOI: 10.1093/bioinformatics/btad093
Abstract: Abstract Summary Without relying on cultivation, metagenomic sequencing greatly accelerated the novel RNA virus detection. However, it is not trivial to accurately identify RNA viral contigs from a mixture of species. The low content of… read more here.
Keywords: rna viral; rna; rna virus; detector ... See more keywords
Production of high‐titer transmission‐defective RNA virus‐based episomal vector using tangential flow filtration
Sign Up to like & getrecommendations! Published in 2020 at "Microbiology and Immunology"
DOI: 10.1111/1348-0421.12831
Abstract: In recent years, viral vector based in vivo gene delivery strategies have achieved a significant success in the treatment of genetic diseases. RNA virus‐based episomal vector lacking viral glycoprotein gene (ΔG‐REVec) is a nontransmissive gene… read more here.
Keywords: vector; virus based; high titer; gene ... See more keywords
Cryptic and abundant marine viruses at the evolutionary origins of Earth’s RNA virome
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DOI: 10.1126/science.abm5847
Abstract: Whereas DNA viruses are known to be abundant, diverse, and commonly key ecosystem players, RNA viruses are insufficiently studied outside disease settings. In this study, we analyzed ≈28 terabases of Global Ocean RNA sequences to… read more here.
Keywords: rna; earth rna; rna virus; evolutionary origins ... See more keywords
Interferon-Independent Restriction of RNA Virus Entry and Replication by a Class of Damage-Associated Molecular Patterns
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DOI: 10.1128/mbio.00584-21
Abstract: In this work, we explored how a class of oxidized lipids, spontaneously created during tissue damage and unprogrammed cell lysis, block the earliest events in RNA virus infection in the human epithelium. This gives us… read more here.
Keywords: associated molecular; rna virus; infection; damage ... See more keywords
Detection of Leishmania RNA Virus 1 in Leishmania (Viannia) panamensis Isolates, Panama
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DOI: 10.3201/eid2906.220012
Abstract: We detected Leishmania RNA virus 1 (LRV1) in 11 isolates of Leishmania (Viannia) panamensis collected during 2014–2019 from patients from different geographic areas in Panama. The distribution suggested a spread of LRV1 in L. (V.)… read more here.
Keywords: leishmania rna; viannia panamensis; panamensis; leishmania ... See more keywords
Hot, Humid Air Decontamination of Aircraft Confirmed That High Temperature and High Humidity Are Critical for Inactivation of Infectious, Enveloped Ribonucleic Acid (RNA) Virus
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2020.592621
Abstract: Aims: To develop infectious (live/dead) enveloped virus test indicators and response surface methodology (RSM) models that evaluate survival of an enveloped ribonucleic acid (RNA) virus on contaminated aircraft materials after exposure to hot, humid air… read more here.
Keywords: aircraft; enveloped ribonucleic; decontamination; inactivation ... See more keywords
RNA Virus Gene Signatures Detected in Patients With Cardiomyopathy After Chemotherapy; A Pilot Study
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.821162
Abstract: Background Viral infections are pervasive and leading causes of myocarditis. Immune-suppression after chemotherapy increases opportunistic infections, but the incidence of virus-induced myocarditis is unknown. Objective An unbiased, blinded screening for RNA viruses was performed after… read more here.
Keywords: cardiomyopathy chemotherapy; patients cardiomyopathy; rna virus; virus ... See more keywords