Sponges and Predators in the Small RNA World.
Sign Up to like & getrecommendations! Published in 2018 at "Microbiology spectrum"
DOI: 10.1128/microbiolspec.rwr-0021-2018
Abstract: Most noncoding small RNAs (sRNAs) that regulate gene expression do so by base-pairing with mRNAs, affecting their translation and/or stability. Regulators as evolutionarily distant as the trans-encoded sRNAs of bacteria and the microRNAs (miRNAs) of… read more here.
Keywords: small rna; rna world; predators small; sponges predators ... See more keywords
On the origin of life: an RNA-focused synthesis and narrative.
Sign Up to like & getrecommendations! Published in 2023 at "RNA"
DOI: 10.1261/rna.079598.123
Abstract: Darwin's assertion that "it is mere rubbish thinking, at present, of origin of life" (quoted from Peretó et al. 2009) is no longer valid. By synthesizing origin of life (OoL) research from its inception to… read more here.
Keywords: synthesis; origin life; life; rna world ... See more keywords
Multi-agent approach to sequence structure simulation in the RNA World hypothesis
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0238253
Abstract: The origins of life on Earth have been the subject of inquiry since the early days of philosophical thought and are still intensively investigated by the researchers around the world. One of the theories explaining… read more here.
Keywords: world hypothesis; sequence structure; world; life ... See more keywords
RNA World Modeling: A Comparison of Two Complementary Approaches
Sign Up to like & getrecommendations! Published in 2022 at "Entropy"
DOI: 10.3390/e24040536
Abstract: Simple Summary Despite years of dedicated research, scientists are still not sure what the first ”living” cell would have looked like. One of the most well-known hypotheses is the RNA world hypothesis, which assumes that,… read more here.
Keywords: world; rna world; modeling comparison; comparison two ... See more keywords
Rolling Circles as a Means of Encoding Genes in the RNA World
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DOI: 10.3390/life12091373
Abstract: The rolling circle mechanism found in viroids and some RNA viruses is a likely way that replication could have begun in the RNA World. Here, we consider simulations of populations of protocells, each containing multiple… read more here.
Keywords: rna world; rolling circles; sequence; rolling circle ... See more keywords
Towards an RNA/Peptides World by the Direct RNA Template Mechanism: The Emergence of Membrane-Stabilizing Peptides in RNA-Based Protocells
Sign Up to like & getrecommendations! Published in 2023 at "Life"
DOI: 10.3390/life13020523
Abstract: How functional peptides may have arisen is a significant problem for the scenario of the RNA world. An attractive idea, the direct RNA template (DRT) hypothesis, proposes that RNA molecules can bind amino acids specifically… read more here.
Keywords: world; rna peptides; rna; membrane ... See more keywords
Order and Complexity in the RNA World
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DOI: 10.3390/life13030603
Abstract: The basic idea of the RNA world as an early step towards life relies on a molecular evolution process based on self-replicating RNA strands. It is probably the oldest and most convincing model for efficient… read more here.
Keywords: order complexity; rna world; order; complexity ... See more keywords
Kin Selection in the RNA World
Sign Up to like & getrecommendations! Published in 2017 at "Life"
DOI: 10.3390/life7040053
Abstract: Various steps in the RNA world required cooperation. Why did life’s first inhabitants, from polymerases to synthetases, cooperate? We develop kin selection models of the RNA world to answer these questions. We develop a very… read more here.
Keywords: rna world; kin selection; cooperation; selection rna ... See more keywords