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   Articles with "rna world" as a keyword



Prebiotic chiral transfer from self-aminoacylating ribozymes may favor either handedness

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-52362-x

Abstract: Modern life is essentially homochiral, containing D-sugars in nucleic acid backbones and L-amino acids in proteins. Since coded proteins are theorized to have developed from a prebiotic RNA World, the homochirality of L-amino acids observed… read more here.

Keywords: self aminoacylating; rna world; amino acids; rna ... See more keywords

Circular at the very beginning: on the initial genomes in the RNA world

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recommendations! Published in 2024 at "RNA Biology"

DOI: 10.1080/15476286.2024.2380130

Abstract: ABSTRACT It is likely that an RNA world existed in early life, when RNA played both the roles of the genome and functional molecules, thereby undergoing Darwinian evolution. However, even with only one type of… read more here.

Keywords: circular beginning; rna world; world; circular genome ... See more keywords

Origin & influence of autocatalytic reaction networks at the advent of the RNA world

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recommendations! Published in 2024 at "RNA Biology"

DOI: 10.1080/15476286.2024.2405757

Abstract: ABSTRACT Research on the origin of life investigates the transition from abiotic chemistry to the emergence of biology, with the ‘RNA world hypothesis’ as the leading theory. RNA’s dual role in storage and catalysis suggests… read more here.

Keywords: chemistry; origin; rna world; biology ... See more keywords
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Sponges and Predators in the Small RNA World.

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recommendations! Published in 2018 at "Microbiology spectrum"

DOI: 10.1128/microbiolspec.rwr-0021-2018

Abstract: Most noncoding small RNAs (sRNAs) that regulate gene expression do so by base-pairing with mRNAs, affecting their translation and/or stability. Regulators as evolutionarily distant as the trans-encoded sRNAs of bacteria and the microRNAs (miRNAs) of… read more here.

Keywords: small rna; rna world; predators small; sponges predators ... See more keywords

On the origin of life: an RNA-focused synthesis and narrative.

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recommendations! Published in 2023 at "RNA"

DOI: 10.1261/rna.079598.123

Abstract: Darwin's assertion that "it is mere rubbish thinking, at present, of origin of life" (quoted from Peretó et al. 2009) is no longer valid. By synthesizing origin of life (OoL) research from its inception to… read more here.

Keywords: synthesis; origin life; life; rna world ... See more keywords
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Multi-agent approach to sequence structure simulation in the RNA World hypothesis

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recommendations! Published in 2020 at "PLoS ONE"

DOI: 10.1371/journal.pone.0238253

Abstract: The origins of life on Earth have been the subject of inquiry since the early days of philosophical thought and are still intensively investigated by the researchers around the world. One of the theories explaining… read more here.

Keywords: world hypothesis; sequence structure; world; life ... See more keywords
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RNA World Modeling: A Comparison of Two Complementary Approaches

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recommendations! Published in 2022 at "Entropy"

DOI: 10.3390/e24040536

Abstract: Simple Summary Despite years of dedicated research, scientists are still not sure what the first ”living” cell would have looked like. One of the most well-known hypotheses is the RNA world hypothesis, which assumes that,… read more here.

Keywords: world; rna world; modeling comparison; comparison two ... See more keywords

Rolling Circles as a Means of Encoding Genes in the RNA World

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recommendations! Published in 2022 at "Life"

DOI: 10.3390/life12091373

Abstract: The rolling circle mechanism found in viroids and some RNA viruses is a likely way that replication could have begun in the RNA World. Here, we consider simulations of populations of protocells, each containing multiple… read more here.

Keywords: rna world; rolling circles; sequence; rolling circle ... See more keywords

Towards an RNA/Peptides World by the Direct RNA Template Mechanism: The Emergence of Membrane-Stabilizing Peptides in RNA-Based Protocells

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recommendations! Published in 2023 at "Life"

DOI: 10.3390/life13020523

Abstract: How functional peptides may have arisen is a significant problem for the scenario of the RNA world. An attractive idea, the direct RNA template (DRT) hypothesis, proposes that RNA molecules can bind amino acids specifically… read more here.

Keywords: world; rna peptides; rna; membrane ... See more keywords

Order and Complexity in the RNA World

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recommendations! Published in 2023 at "Life"

DOI: 10.3390/life13030603

Abstract: The basic idea of the RNA world as an early step towards life relies on a molecular evolution process based on self-replicating RNA strands. It is probably the oldest and most convincing model for efficient… read more here.

Keywords: order complexity; rna world; order; complexity ... See more keywords

Origin of the RNA World in Cold Hadean Geothermal Fields Enriched in Zinc and Potassium: Abiogenesis as a Positive Fallout from the Moon-Forming Impact?

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recommendations! Published in 2025 at "Life"

DOI: 10.3390/life15030399

Abstract: The ubiquitous, evolutionarily oldest RNAs and proteins exclusively use rather rare zinc as transition metal cofactor and potassium as alkali metal cofactor, which implies their abundance in the habitats of the first organisms. Intriguingly, lunar… read more here.

Keywords: rna world; origin rna; zinc; moon ... See more keywords