Engineered Hydrogels for Local and Sustained Delivery of RNA-Interference Therapies.
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DOI: 10.1002/adhm.201601041
Abstract: It has been nearly two decades since RNA-interference (RNAi) was first reported. While there are no approved clinical uses, several phase II and III clinical trials suggest the great promise of RNAi therapeutics. One challenge… read more here.
Keywords: local sustained; hydrogels local; rna interference; rnai ... See more keywords
Cation-Free siRNA Micelles as Effective Drug Delivery Platform and Potent RNAi Nanomedicines for Glioblastoma Therapy.
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DOI: 10.1002/adma.202104779
Abstract: Nanoparticle-based small interfering RNA (siRNA) therapy shows great promise for glioblastoma (GBM). However, charge associated toxicity and limited blood-brain-barrier (BBB) penetration remain significant challenges for siRNA delivery for GBM therapy. Herein, novel cation-free siRNA micelles,… read more here.
Keywords: sirna micelles; rnai; drug; cation free ... See more keywords
Systemic RNAi in the small hive beetle Aethina tumida Murray (Coleoptera: Nitidulidae), a serious pest of the European honey bee Apis mellifera.
Sign Up to like & getrecommendations! Published in 2017 at "Pest management science"
DOI: 10.1002/ps.4365
Abstract: BACKGROUND Aethina tumida is a serious pest of the European honey bee (Apis mellifera) in North America and Australia. Here we investigate whether Laccase 2, the phenoloxidase gene essential for cuticle sclerotisation and pigmentation in… read more here.
Keywords: pest european; honey; aethina tumida; rnai ... See more keywords
Double-stranded RNA delivery through soaking mediates silencing of the muscle protein 20 and increases mortality to the Asian citrus psyllid, Diaphorina citri.
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DOI: 10.1002/ps.4549
Abstract: BACKGROUND Asian citrus psyllid, Diaphorina citri Kuwayama, is the most important economic pest of citrus because it transmits Candidatus Liberibacter asiaticus (CLas), the causal agent of huanglongbing (HLB). Silencing genes by RNA interference (RNAi) is… read more here.
Keywords: muscle; rnai; asian citrus; dcmp20 ... See more keywords
Nanomaterial-wrapped dsCYP15C1, a potential RNAi-based strategy for pest control against Chilo suppressalis.
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DOI: 10.1002/ps.5789
Abstract: BACKGROUND Although the utility of dsRNA-mediated knockdown as an environmentally friendly pest management strategy has gained traction in recent years, its overall efficacy has been limited by poor stability and limited cellular uptake. The encapsulation… read more here.
Keywords: chilo suppressalis; rnai; mediated knockdown; strategy ... See more keywords
RNAi-mediated mortality in Southern green stinkbug Nezara viridula by oral delivery of dsRNA.
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DOI: 10.1002/ps.6017
Abstract: BACKGROUND The southern green stinkbug, Nezara viridula (Hemiptera: Pentatomidae), is an important emerging polyphagous pest infesting soybean in the United States, Brazil and Argentina. The indiscriminate use of synthetic insecticides to control stinkbugs has limited… read more here.
Keywords: oral delivery; rnai; mortality; delivery dsrna ... See more keywords
RNA meets toxicology: efficacy indicators from the experimental design of RNAi studies for insect pest management
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DOI: 10.1002/ps.6884
Abstract: Abstract RNA interference (RNAi) selectively targets genes and silences their expression in vivo, causing developmental defects, mortality and altered behavior. Consequently, RNAi has emerged as a promising research area for insect pest management. However, it… read more here.
Keywords: toxicology; insect pest; rna; management ... See more keywords
Development of efficient RNAi methods in the corn leafhopper Dalbulus maidis, a promising application for pest control.
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DOI: 10.1002/ps.6937
Abstract: BACKGROUND The corn leafhopper Dalbulus maidis is the main vector of important stunting pathogens that affect maize production. Currently, there are no effective methods available to manage this pest without adverse impact on the environment.… read more here.
Keywords: corn leafhopper; rnai; control; dalbulus maidis ... See more keywords
Knockdown of Hexokinase in Diaphorina citri Kuwayama (Hemiptera: Liviidae) by RNAi Inhibits Chitin Synthesis and leads to abnormal phenotypes.
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DOI: 10.1002/ps.7049
Abstract: BACKGROUND Silencing specific genes in pests through RNA interference technology is a promising new pest-control strategy. The Asian citrus psyllid, Diaphorina citri Kuwayama, is the most important citrus pest because it transmits Candidatus Liberibacter asiaticus,… read more here.
Keywords: chitin synthesis; diaphorina citri; citri kuwayama; citri ... See more keywords
Bacteria-mediated RNAi for managing fall webworm, Hyphantria cunea: screening target genes and analyzing lethal effect.
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DOI: 10.1002/ps.7326
Abstract: BACKGROUND The fall webworm, Hyphantria cunea, an invasive forest pest found worldwide, causes serious ecological and economic damage. Currently, the application of chemical pesticides is the most widely used strategy for H. cunea management. However,… read more here.
Keywords: fall webworm; cunea; hyphantria cunea; webworm hyphantria ... See more keywords
Redox-Responsive Nanoparticle-Mediated Systemic RNAi for Effective Cancer Therapy.
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DOI: 10.1002/smll.201802565
Abstract: Biodegradable polymeric nanoparticles (NPs) have demonstrated significant potential to improve the systemic delivery of RNA interference (RNAi) therapeutics, such as small interfering RNA (siRNA), for cancer therapy. However, the slow and inefficient siRNA release inside… read more here.
Keywords: redox responsive; sirna; cancer therapy; rnai ... See more keywords