A Review of pH-Responsive Organic-Inorganic Hybrid Nanoparticles for RNAi-Based Therapeutics.
Sign Up to like & getrecommendations! Published in 2021 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202100183
Abstract: RNA interference (RNAi) shows great potential in the treatment of varying cancer and genetic disorders. The lack of safe and effective delivery methods is an ongoing challenge to realize the full potential of RNAi-based therapeutics.… read more here.
Keywords: organic inorganic; delivery; responsive organic; based therapeutics ... See more keywords
Identification and RNAi-based function analysis of chitinase family genes in diamondback moth, Plutella xylostella.
Sign Up to like & getrecommendations! Published in 2019 at "Pest management science"
DOI: 10.1002/ps.5308
Abstract: BACKGROUND Insect chitinases play a vital part in chitin degradation in exoskeletons and gut linings during the molting process, and therefore are considered potential targets for new insecticide designs or RNA interference (RNAi)-based pest management.… read more here.
Keywords: xylostella; rnai based; analysis chitinase; chitinase ... See more keywords
Identification and RNAi-based functional analysis of chitinase family genes in Agrotis ipsilon.
Sign Up to like & getrecommendations! Published in 2022 at "Pest management science"
DOI: 10.1002/ps.7047
Abstract: BACKGROUND Chitin is a major component in the extracellular matrix of insects, and its metabolism largely affects insect development and molting. As essential degradative enzymes, chitinases are encoded by multiple genes that differ in size,… read more here.
Keywords: chitinase; agrotis ipsilon; insects; expression ... See more keywords
Circulating Immune Cells Mediate a Systemic RNAi-Based Adaptive Antiviral Response in Drosophila
Sign Up to like & getrecommendations! Published in 2017 at "Cell"
DOI: 10.1016/j.cell.2017.03.033
Abstract: Effective antiviral protection in multicellular organisms relies on both cell-autonomous and systemic immunity. Systemic immunity mediates the spread of antiviral signals from infection sites to distant uninfected tissues. In arthropods, RNA interference (RNAi) is responsible… read more here.
Keywords: systemic rnai; rnai; systemic immunity; rnai based ... See more keywords
Does RNAi-Based Technology Fit within EU Sustainability Goals?
Sign Up to like & getrecommendations! Published in 2020 at "Trends in biotechnology"
DOI: 10.1016/j.tibtech.2020.11.008
Abstract: European Union (EU) and global sustainability policies emphasize the need to replace contentious pesticides with safe, efficient, and cost-effective alternatives to ensure sustainable food production. However, R&D for alternatives to contentious pesticides are lagging behind… read more here.
Keywords: technology fit; based technology; rnai based; fit within ... See more keywords
RNAi-based bioinsecticide for Aedes mosquito control
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-39666-5
Abstract: Zika virus infection and dengue and chikungunya fevers are emerging viral diseases that have become public health threats. Their aetiologic agents are transmitted by the bite of genus Aedes mosquitoes. Without effective therapies or vaccines,… read more here.
Keywords: bioinsecticide aedes; control; rnai based; mosquito control ... See more keywords
Abstract 5069: Cancer immunotherapy based on the RNAi-based PD-L1 inhibitor, MN-siPDL1, demonstrates efficacy in preclinical pancreatic adenocarcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5069
Abstract: The recent past has seen impressive progress in the treatment of various malignancies using immunotherapy. One of the most promising approaches involves immune checkpoint inhibition, mainly relying on monoclonal antibodies or small molecules. With specific… read more here.
Keywords: inhibitor; checkpoint; sipdl1; tumor ... See more keywords
Effect of RNAi-based β-catenin inhibition on immunosuppressive Wnt-activated tumors in combination with IDOi/PD-1 immunotherapy.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e15038
Abstract: e15038Background: Wnt/β-catenin pathway activation has been correlated with T-cell exclusion across most human tumors. Additionally, Wnt signaling promotes constitutive IDO1 expression in some tumo... read more here.
Keywords: effect rnai; catenin inhibition; immunosuppressive wnt; based catenin ... See more keywords
CRISPR/Cas- and Topical RNAi-Based Technologies for Crop Management and Improvement: Reviewing the Risk Assessment and Challenges Towards a More Sustainable Agriculture
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.913728
Abstract: Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated gene (Cas) system and RNA interference (RNAi)-based non-transgenic approaches are powerful technologies capable of revolutionizing plant research and breeding. In recent years, the use of these modern technologies… read more here.
Keywords: crop; risk assessment; rnai; topical rnai ... See more keywords
Application progress of plant-mediated RNAi in pest control
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.963026
Abstract: RNA interference (RNAi)-based biopesticides are novel biologic products, developed using RNAi principles. They are engineered to target genes of agricultural diseases, insects, and weeds, interfering with their target gene expression so as to hinder their… read more here.
Keywords: rnai pest; pest control; plant; based biopesticides ... See more keywords
RNAi-Based Identification of Gene-Specific Nuclear Cofactor Networks Regulating Interleukin-1 Target Genes
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.00775
Abstract: The potent proinflammatory cytokine interleukin (IL)-1 triggers gene expression through the NF-κB signaling pathway. Here, we investigated the cofactor requirements of strongly regulated IL-1 target genes whose expression is impaired in p65 NF-κB-deficient murine embryonic… read more here.
Keywords: target genes; target; rnai based; gene ... See more keywords