Expanded CUG Repeats Trigger Disease Phenotype and Expression Changes through the RNAi Machinery in C. elegans.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.03.003
Abstract: Myotonic dystrophy type 1 is an autosomal-dominant inherited disorder caused by the expansion of CTG repeats in the 3' untranslated region of the DMPK gene. The RNAs bearing these expanded repeats have a range of… read more here.
Keywords: repeats trigger; trigger disease; expanded cug; machinery ... See more keywords
How RNAi machinery enters the world of telomerase
Sign Up to like & getrecommendations! Published in 2019 at "Cell Cycle"
DOI: 10.1080/15384101.2019.1609834
Abstract: ABSTRACT Human telomerase holoenzyme consists of the catalytic component TERT and the template RNA TERC. However, a network of accessory proteins plays key roles in its assembly, localization and stability. Defects in genes involved in… read more here.
Keywords: telomerase; rnai machinery; machinery enters; world telomerase ... See more keywords
RNAi machinery regulates nutrient metabolism and fluconazole resistance in the pathogenic fungus Cryptococcus deneoformans.
Sign Up to like & getrecommendations! Published in 2022 at "Medical mycology"
DOI: 10.1093/mmy/myac095
Abstract: The RNAi machinery has been extensively studied in plant and animal cells for their crucial roles in regulation of genome function. However, the potential roles of RNAi in controlling fungal growth and development have been… read more here.
Keywords: cryptococcus deneoformans; fluconazole resistance; resistance; rnai machinery ... See more keywords