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Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac072
Abstract: Abstract Ribosome assembly is an essential process that is linked to human congenital diseases and tumorigenesis. While great progress has been made in deciphering mechanisms governing ribosome biogenesis in eukaryotes, an inventory of factors that…
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Keywords:
60s subunit;
polyamine metabolism;
wide rnai;
enzymes polyamine ... See more keywords
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2
Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1084
Abstract: Abstract RNA helicases are involved in multiple steps of RNA metabolism to direct their roles in gene expression, yet their functions in pluripotency control remain largely unexplored. Starting from an RNA interference (RNAi) screen of…
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Keywords:
cell;
rnai screen;
rna helicases;
pluripotency ... See more keywords
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Published in 2021 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noab090.008
Abstract: Abstract ATRT of the CNS constitute a group of rare and aggressive early childhood tumors with poor prognosis. While there are differing chemotherapeutic regimens for ATRT, high-dose MTX is a crucial component of many therapeutic…
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Keywords:
genome wide;
wide rnai;
mtx resistance;
resistance ... See more keywords
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Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aax0365
Abstract: Dhpr regulates mitochondrial morphology by modulating S-nitrosylation of Drp1. Mitochondria are highly dynamic organelles. Through a large-scale in vivo RNA interference (RNAi) screen that covered around a quarter of the Drosophila melanogaster genes (4000 genes),…
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Keywords:
large scale;
mitochondrial morphology;
morphology;
morphology tissue ... See more keywords
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Published in 2020 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1008220
Abstract: The intracellular lifestyle of Salmonella enterica is characterized by the formation of a replication-permissive membrane-bound niche, the Salmonella-containing vacuole (SCV). As a further consequence of the massive remodeling of the host cell endosomal system, intracellular…
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Keywords:
fusion;
salmonella;
intracellular salmonella;
host ... See more keywords
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1
Published in 2017 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2017.00141
Abstract: Synaptic vesicles (SV) store various neurotransmitters that are released at the synapse. The molecular mechanisms of biogenesis, exocytosis, and endocytosis for SV, however, remain largely elusive. In this study, using Complex Object Parametric Analysis and…
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Keywords:
spindle assembly;
checkpoint protein;
screen;
protein bugz ... See more keywords