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   Articles with "rnapii" as a keyword



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Size-Dependent Increase in RNA Polymerase II Initiation Rates Mediates Gene Expression Scaling with Cell Size

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recommendations! Published in 2020 at "Current Biology"

DOI: 10.1016/j.cub.2020.01.053

Abstract: Cell size varies during the cell cycle and in response to external stimuli. This requires the tight coordination, or "scaling," of mRNA and protein quantities with the cell volume in order to maintain biomolecule concentrations… read more here.

Keywords: transcription; scaling cell; size; rnapii ... See more keywords
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Topoisomerase 1 activity during mitotic transcription favors the transition from mitosis to G1.

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recommendations! Published in 2021 at "Molecular cell"

DOI: 10.1016/j.molcel.2021.10.015

Abstract: As cells enter mitosis, chromatin compacts to facilitate chromosome segregation yet remains transcribed. Transcription supercoils DNA to levels that can impede further progression of RNA polymerase II (RNAPII) unless it is removed by DNA topoisomerase… read more here.

Keywords: transcription; mitosis; top1; mitotic transcription ... See more keywords
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AGR2-dependent nuclear import of RNA polymerase II constitutes a specific target of pancreatic ductal adenocarcinoma in the context of wild-type p53.

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recommendations! Published in 2021 at "Gastroenterology"

DOI: 10.1053/j.gastro.2021.07.030

Abstract: BACKGROUND AND AIM Promoted by pancreatitis, oncogenic KrasG12D triggers acinar cells' neoplastic transformation through acinar-to-ductal metaplasia (ADM) and pancreatic intraepithelial neoplasia (PanIN). Agr2 (anterior gradient 2), a known inhibitor of p53, is detected at early… read more here.

Keywords: rnapii; wild type; type p53; nuclear import ... See more keywords

Mitotically heritable, RNA polymerase II-independent H3K4 dimethylation stimulates INO1 transcriptional memory

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recommendations! Published in 2022 at "eLife"

DOI: 10.1101/2022.02.11.480054

Abstract: For some inducible genes, the rate and molecular mechanism of transcriptional activation depends on the prior experiences of the cell. This phenomenon, called epigenetic transcriptional memory, accelerates reactivation and requires both changes in chromatin structure… read more here.

Keywords: transcriptional memory; rna polymerase; rnapii; memory ... See more keywords
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The SPARC complex defines RNAPII promoters in Trypanosoma brucei

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recommendations! Published in 2022 at "eLife"

DOI: 10.1101/2022.07.14.499694

Abstract: Kinetoplastids are a highly divergent lineage of eukaryotes with unusual mechanisms for regulating gene expression. We previously surveyed 65 putative chromatin factors in the kinetoplastid Trypanosoma brucei. Our analyses revealed that the predicted histone methyltransferase… read more here.

Keywords: trypanosoma brucei; complex defines; rnapii; defines rnapii ... See more keywords
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A transcriptionally repressed quiescence program is associated with paused RNAPII and is poised for cell cycle reentry.

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recommendations! Published in 2022 at "Journal of cell science"

DOI: 10.1242/jcs.259789

Abstract: Adult stem cells persist in mammalian tissues by entering a state of reversible quiescence/ G0, associated with low transcription. Using cultured myoblasts and muscle stem cells, we report that in G0, global RNA content and… read more here.

Keywords: cell; repressed quiescence; quiescence; rnapii ... See more keywords

The role of p53 in the DNA damage-related ubiquitylation of S2P RNAPII

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recommendations! Published in 2022 at "PLoS ONE"

DOI: 10.1371/journal.pone.0267615

Abstract: DNA double-strand breaks are one of the most deleterious lesions for the cells, therefore understanding the macromolecular interactions of the DNA repair-related mechanisms is essential. DNA damage triggers transcription silencing at the damage site, leading… read more here.

Keywords: damage; role; rnapii; p53 ... See more keywords
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tRIP‐seq reveals repression of premature polyadenylation by co‐transcriptional FUS‐U1 snRNP assembly

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recommendations! Published in 2020 at "EMBO reports"

DOI: 10.15252/embr.201949890

Abstract: RNA processing occurs co‐transcriptionally through the dynamic recruitment of RNA processing factors to RNA polymerase II (RNAPII). However, transcriptome‐wide identification of protein–RNA interactions specifically assembled on transcribing RNAPII is challenging. Here, we develop the targeted… read more here.

Keywords: rna; trip; trip seq; fus snrnp ... See more keywords
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Establishment and inheritance of epigenetic transcriptional memory

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recommendations! Published in 2022 at "Frontiers in Molecular Biosciences"

DOI: 10.3389/fmolb.2022.977653

Abstract: For certain inducible genes, the rate and molecular mechanism of transcriptional activation depends on the prior experiences of the cell. This phenomenon, called epigenetic transcriptional memory, accelerates reactivation and requires both changes in chromatin structure… read more here.

Keywords: transcriptional memory; epigenetic transcriptional; rnapii; establishment inheritance ... See more keywords
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PIP2-Effector Protein MPRIP Regulates RNA Polymerase II Condensation and Transcription

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recommendations! Published in 2023 at "Biomolecules"

DOI: 10.3390/biom13030426

Abstract: The specific post-translational modifications of the C-terminal domain (CTD) of the Rpb1 subunit of RNA polymerase II (RNAPII) correlate with different stages of transcription. The phosphorylation of the Ser5 residues of this domain associates with… read more here.

Keywords: ctd; transcription; rnapii; protein mprip ... See more keywords
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Slow RNAPII Transcription Elongation Rate, Low Levels of RNAPII Pausing, and Elevated Histone H1 Content at Promoters Associate with Higher m6A Deposition on Nascent mRNAs

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recommendations! Published in 2022 at "Genes"

DOI: 10.3390/genes13091652

Abstract: N6-methyladenosine modification (m6A) fine-tunes RNA fate in a variety of ways, thus regulating multiple fundamental biological processes. m6A writers bind to chromatin and interact with RNA polymerase II (RNAPII) during transcription. To evaluate how the… read more here.

Keywords: histone; deposition; rnapii; rnapii transcription ... See more keywords