Multi-omics to characterize the functional relationships of R-loops with epigenetic modifications, RNAPII transcription and gene expression
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac238
Abstract: Abnormal accumulation of R-loops results in replication stress, genome instability, chromatin alterations and gene silencing. Little research has been done to characterize functional relationships among R-loops, histone marks, RNA polymerase II (RNAPII) transcription and gene… read more here.
Keywords: characterize functional; transcription; functional relationships; rnapii transcription ... See more keywords
Slow RNAPII Transcription Elongation Rate, Low Levels of RNAPII Pausing, and Elevated Histone H1 Content at Promoters Associate with Higher m6A Deposition on Nascent mRNAs
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13091652
Abstract: N6-methyladenosine modification (m6A) fine-tunes RNA fate in a variety of ways, thus regulating multiple fundamental biological processes. m6A writers bind to chromatin and interact with RNA polymerase II (RNAPII) during transcription. To evaluate how the… read more here.
Keywords: histone; deposition; rnapii; rnapii transcription ... See more keywords