ISG20: an enigmatic antiviral RNase targeting multiple viruses
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13382
Abstract: Interferon‐stimulated gene 20 kDa protein (ISG20) is a relatively understudied antiviral protein capable of inhibiting a broad spectrum of viruses. ISG20 exhibits strong RNase properties, and it belongs to the large family of DEDD exonucleases, present… read more here.
Keywords: viruses isg20; isg20 enigmatic; rnase targeting; antiviral rnase ... See more keywords
Rapid detection of RNase‐based self‐incompatibility in Lysimachia monelli (Primulaceae)
Sign Up to like & getrecommendations! Published in 2025 at "American Journal of Botany"
DOI: 10.1002/ajb2.16449
Abstract: Abstract Premise Primroses famously employ a system that simultaneously expresses distyly and filters out self‐pollen. Other species in the Primulaceae family, including Lysimachia monelli (blue pimpernel), also express self‐incompatibility (SI), but involving a system with… read more here.
Keywords: detection; rnase; rnase based; self incompatibility ... See more keywords
Target-Activated DNA Polymerase Activity for Sensitive RNase H Activity Assay.
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DOI: 10.1002/biot.201800645
Abstract: Herein, the ribonuclease H (RNase H) activity assay based on the target-activated DNA polymerase activity is described. In this method, a detection probe composed of two functional sequences, a binding site for DNA polymerase and… read more here.
Keywords: rnase activity; rnase; dna polymerase; activity ... See more keywords
The Association of RNase L, Cytokines, and Chemokines With Severity of Multisystem Inflammatory Syndrome in Children
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Medical Virology"
DOI: 10.1002/jmv.70650
Abstract: The 2′,5′‐oligoadenylate synthetase (OAS)‐ribonuclease L (RNase L) system, induced by type I interferons, defends against RNA viruses. Inborn errors in this pathway may trigger inflammatory cytokines, contributing to SARS‐CoV‐2‐related multisystem inflammatory syndrome in children (MIS‐C).… read more here.
Keywords: rnase; severity; inflammatory syndrome; multisystem inflammatory ... See more keywords
Genome‐wide screening of potential RNase Y‐processed mRNAs in the M49 serotype Streptococcus pyogenes NZ131
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DOI: 10.1002/mbo3.671
Abstract: RNase Y is a major endoribonuclease in Group A streptococcus (GAS) and other Gram‐positive bacteria. Our previous study showed that RNase Y was involved in mRNA degradation and processing in GAS. We hypothesized that mRNA… read more here.
Keywords: streptococcus pyogenes; mrna processing; rnase processed; rnase ... See more keywords
Circular zymogens of human ribonuclease 1
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DOI: 10.1002/pro.3686
Abstract: The endogenous production of enzymes as zymogens provides a means to control catalytic activities. Here, we describe the heterologous production of ribonuclease 1 (RNase 1), which is the most prevalent secretory ribonuclease in humans, as… read more here.
Keywords: protease; zymogens human; rnase; circular zymogens ... See more keywords
Ribonuclease T2 represents a distinct circularly permutated version of the BECR RNases
Sign Up to like & getrecommendations! Published in 2022 at "Protein Science"
DOI: 10.1002/pro.4531
Abstract: Detection of homologous relationships among proteins and understanding their mechanisms of diversification are major topics in the fields of protein science, bioinformatics, and phylogenetics. Recent developments in sequence/profile‐based and structural similarity‐based methods have greatly facilitated… read more here.
Keywords: becr; becr rnases; permutated version; circularly permutated ... See more keywords
Fluorescence-Based Real-Time Activity Assays to Identify RNase P Inhibitors.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6634-9_12
Abstract: Transfer RNA is transcribed as precursor molecules that are processed before participating in translation catalyzed by the ribosome. Ribonuclease P is the endonuclease that catalyzes the 5' end maturation of precursor tRNA and it is… read more here.
Keywords: real time; fluorescence based; rnase; based real ... See more keywords
Analysis of Mitochondrial RNA-Processing Defects in Patient-Derived Tissues by qRT-PCR and RNAseq.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6824-4_23
Abstract: Transcription of the mitochondrial genome yields three large polycistronic transcripts that undergo multiple endonucleolytic processing steps, before resulting in functional mRNAs, tRNAs, and rRNAs. Cleavage of the large precursor transcripts is mainly performed by the… read more here.
Keywords: pcr rnaseq; processing; rnase; rna processing ... See more keywords
RNases H1 and H2: guardians of the stability of the nuclear genome when supply of dNTPs is limiting for DNA synthesis.
Sign Up to like & getrecommendations! Published in 2020 at "Current genetics"
DOI: 10.1007/s00294-020-01086-8
Abstract: RNA/DNA hybrids are processed by RNases H1 and H2, while single ribonucleoside-monophosphates (rNMPs) embedded in genomic DNA are removed by the error-free, RNase H2-dependent ribonucleotide excision repair (RER) pathway. In the absence of RER, however,… read more here.
Keywords: genomic rnmps; rnase; supply dntps; dna ... See more keywords
Advances in preparation of acellular human dermis for tissue banking and transplantation
Sign Up to like & getrecommendations! Published in 2024 at "Cell and Tissue Banking"
DOI: 10.1007/s10561-024-10153-0
Abstract: Non-healing wounds cost the National Health Service over £5.6 billion annually in wound management. Skin allografts are used to treat non-healing wounds, ulcers and burns, offering the best protection against infection. In order to allow… read more here.
Keywords: rnase; decellularisation; benzonase; dermis ... See more keywords