Crystal structure of human RPP20-RPP25 proteins in complex with the P3 domain of lncRNA RMRP.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of structural biology"
DOI: 10.1016/j.jsb.2021.107704
Abstract: Human RNase MRP ribonucleoprotein complex is an essential endoribonuclease involved in the processing of ribosomal RNAs, mitochondrial RNAs and certain messenger RNAs. Its RNA subunit RMRP catalyzes the cleavage of substrate RNAs, and the protein… read more here.
Keywords: rpp20 rpp25; rnase mrp; rpp20; human rnase ... See more keywords
A disease-linked lncRNA mutation in RNase MRP inhibits ribosome synthesis
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28295-8
Abstract: RMRP encodes a non-coding RNA forming the core of the RNase MRP ribonucleoprotein complex. Mutations cause Cartilage Hair Hypoplasia (CHH), characterized by skeletal abnormalities and impaired T cell activation. Yeast RNase MRP cleaves a specific… read more here.
Keywords: rnase; mutation; pre rrna; rnase mrp ... See more keywords
A novel experimental approach for the selective isolation and characterization of human RNase MRP
Sign Up to like & getrecommendations! Published in 2022 at "RNA Biology"
DOI: 10.1080/15476286.2022.2027659
Abstract: ABSTRACT RNase MRP is a ribonucleoprotein complex involved in the endoribonucleolytic cleavage of different RNAs. Mutations in the RNA component of the RNP are the cause of cartilage hair hypoplasia. Patients with cartilage hair hypoplasia… read more here.
Keywords: mrp; mrp rna; novel experimental; approach ... See more keywords
Structural insight into precursor ribosomal RNA processing by ribonuclease MRP
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.abc0149
Abstract: Adapted to the task at hand RNA-based catalysts perform fundamental tasks in cellular RNA metabolism, especially in eukaryotes, where RNAs are cut by specialized ribonucleoproteins (RNPs) as part of ribosome assembly or messenger RNA regulation… read more here.
Keywords: rnase mrp; microscopy; ribonuclease mrp; ribonuclease ... See more keywords