A role for the periplasmic adaptor protein AcrA in vetting substrate access to the RND efflux transporter AcrB
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-08903-9
Abstract: Tripartite resistance-nodulation-division (RND) efflux pumps, such as AcrAB-TolC of Salmonella Typhimurium, contribute to antibiotic resistance and comprise an inner membrane RND-transporter, an outer membrane factor, and a periplasmic adaptor protein (PAP). The role of the… read more here.
Keywords: transporter; periplasmic adaptor; role; rnd efflux ... See more keywords
AcrAB, the major RND-type efflux pump of Photorhabdus laumondii, confers intrinsic multidrug-resistance and contributes to virulence in insects.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental microbiology reports"
DOI: 10.1111/1758-2229.12974
Abstract: The resistance-nodulation-division (RND)-type efflux pumps AcrAB and MdtABC contribute to multidrug-resistance (MDR) in Gram-negative bacteria. Photorhabdus is a symbiotic bacterium of soil nematodes that also produces virulence factors killing insects by septicaemia. We previously showed… read more here.
Keywords: insects; rnd; laumondii; photorhabdus ... See more keywords
Loss of RND-Type Multidrug Efflux Pumps Triggers Iron Starvation and Lipid A Modifications in Pseudomonas aeruginosa
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DOI: 10.1128/aac.00592-21
Abstract: Transporters belonging to the resistance-nodulation-division (RND) superfamily of proteins are invariably present in the genomes of Gram-negative bacteria and are largely responsible for the intrinsic antibiotic resistance of these organisms. The numbers of genes encoding… read more here.
Keywords: triggers iron; resistance; iron starvation; multidrug ... See more keywords
The Vibrio cholerae VexGH RND Efflux System Maintains Cellular Homeostasis by Effluxing Vibriobactin
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DOI: 10.1128/mbio.00126-17
Abstract: ABSTRACT Resistance-nodulation-division (RND) superfamily efflux systems have been widely studied for their role in antibiotic resistance, but their native biological functions remain poorly understood. We previously showed that loss of RND-mediated efflux in Vibrio cholerae… read more here.
Keywords: rnd; cholerae; vexgh rnd; antimicrobial resistance ... See more keywords
Identification of binding residues between periplasmic adapter protein (PAP) and RND efflux pumps explains PAP-pump promiscuity and roles in antimicrobial resistance
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1008101
Abstract: Active efflux due to tripartite RND efflux pumps is an important mechanism of clinically relevant antibiotic resistance in Gram-negative bacteria. These pumps are also essential for Gram-negative pathogens to cause infection and form biofilms. They… read more here.
Keywords: pap rnd; rnd; pump; resistance ... See more keywords