Reconstitution of the activity of RND efflux pumps: a "bottom-up" approach.
Sign Up to like & getrecommendations! Published in 2018 at "Research in microbiology"
DOI: 10.1016/j.resmic.2017.11.004
Abstract: Efflux pumps are systems devoted to the extrusion of noxious compounds. In this review, we discuss the various strategies that have thus far been undertaken for the investigation of efflux pumps after reconstitution into liposomes.… read more here.
Keywords: activity rnd; rnd efflux; efflux pumps; efflux ... See more keywords
Computer simulations of the activity of RND efflux pumps.
Sign Up to like & getrecommendations! Published in 2018 at "Research in microbiology"
DOI: 10.1016/j.resmic.2017.12.001
Abstract: The putative mechanism by which bacterial RND-type multidrug efflux pumps recognize and transport their substrates is a complex and fascinating enigma of structural biology. How a single protein can recognize a huge number of unrelated… read more here.
Keywords: activity rnd; computer simulations; rnd efflux; efflux pumps ... See more keywords
A role for the periplasmic adaptor protein AcrA in vetting substrate access to the RND efflux transporter AcrB
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-08903-9
Abstract: Tripartite resistance-nodulation-division (RND) efflux pumps, such as AcrAB-TolC of Salmonella Typhimurium, contribute to antibiotic resistance and comprise an inner membrane RND-transporter, an outer membrane factor, and a periplasmic adaptor protein (PAP). The role of the… read more here.
Keywords: transporter; periplasmic adaptor; role; rnd efflux ... See more keywords
Overexpression of Resistance-Nodulation-Division Efflux Pump Genes Contributes to Multidrug Resistance in Aeromonas hydrophila Clinical Isolates.
Sign Up to like & getrecommendations! Published in 2021 at "Microbial drug resistance"
DOI: 10.1089/mdr.2021.0084
Abstract: Aeromonas hydrophila is a Gram-negative bacterium that is a critical causative agent of infections in fish and is occasionally responsible for human infections following contact with contaminated water or food. Currently, the extensive use of… read more here.
Keywords: rnd efflux; resistance; clinical isolates; efflux pump ... See more keywords
Vibrio cholerae OmpR Represses the ToxR Regulon in Response to Membrane Intercalating Agents That Are Prevalent in the Human Gastrointestinal Tract
Sign Up to like & getrecommendations! Published in 2019 at "Infection and Immunity"
DOI: 10.1128/iai.00912-19
Abstract: Multidrug efflux systems belonging to the resistance-nodulation-division (RND) superfamily are ubiquitous in Gram-negative bacteria. RND efflux systems are often associated with multiple antimicrobial resistance and also contribute to the expression of diverse bacterial phenotypes including… read more here.
Keywords: efflux systems; rnd efflux; virulence; vibrio cholerae ... See more keywords
Vibrio cholerae RND efflux systems: mediators of stress responses, colonization and pathogenesis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2023.1203487
Abstract: Resistance Nodulation Division (RND) efflux systems are ubiquitous transporters in gram-negative bacteria that provide protection against antimicrobial agents and thereby enhance survival in virtually all environments these prokaryotes inhabit. Vibrio cholerae is a dual lifestyle… read more here.
Keywords: vibrio cholerae; rnd efflux; efflux systems; colonization ... See more keywords