Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps
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DOI: 10.1038/s41467-021-27726-2
Abstract: Efflux transporters of the RND family confer resistance to multiple antibiotics in Gram-negative bacteria. Here, we identify and chemically optimize pyridylpiperazine-based compounds that potentiate antibiotic activity in E. coli through inhibition of its primary RND… read more here.
Keywords: pyridylpiperazine based; allosteric inhibitors; based allosteric; rnd type ... See more keywords
The role of RND-type efflux pumps in multidrug-resistant mutants of Klebsiella pneumoniae
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DOI: 10.1038/s41598-020-67820-x
Abstract: The emergence of multidrug-resistant Klebsiella pneumoniae is a worldwide problem. K. pneumoniae possesses numerous resistant genes in its genome. We isolated mutants resistant to various antimicrobials in vitro and investigated the importance of intrinsic genes… read more here.
Keywords: rnd type; pneumoniae; resistant mutants; multidrug resistant ... See more keywords
Contribution of RND-Type Efflux Pumps in Reduced Susceptibility to Biocides in Acinetobacter baumannii
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DOI: 10.3390/antibiotics11111635
Abstract: Bacterial efflux pumps are among the key mechanisms of resistance against antibiotics and biocides. We investigated whether differential expression levels of the RND-type efflux pumps AdeABC and AdeIJK impacted the susceptibility to commonly used biocides… read more here.
Keywords: efflux pumps; type efflux; rnd type; expression ... See more keywords