OS12.5 Small GTPase RHOE/RND3, a new critical regulator of NF-êB signaling in glioblastoma multiforme?
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz126.077
Abstract: Abnormal activation of NF-κB signaling is a major mechanism of apoptosis resistance in glioblastoma multiforme (GBM). Therefore, better understanding of the regulation of NF-κB signaling has a significant impact for GBM therapy. Here, we uncovered… read more here.
Keywords: apoptosis; gbm; glioblastoma multiforme; small gtpase ... See more keywords
Rnd3 interacts with TAO kinases and contributes to mitotic cell rounding and spindle positioning
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cell Science"
DOI: 10.1242/jcs.235895
Abstract: ABSTRACT Rnd3 is an atypical Rho family protein that is constitutively GTP bound, and acts on membranes to induce loss of actin stress fibers and cell rounding. Phosphorylation of Rnd3 promotes 14-3-3 binding and its… read more here.
Keywords: mitotic cell; rounding spindle; spindle positioning; cell rounding ... See more keywords
Genetic deletion of Rnd3 in neural stem cells promotes proliferation via upregulation of Notch signaling
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DOI: 10.18632/oncotarget.20247
Abstract: Rnd3, a Rho GTPase, is involved in the inhibition of actin cytoskeleton dynamics through the Rho kinase-dependent signaling pathway. We previously demonstrated that mice with genetic deletion of Rnd3 developed a markedly larger brain compared… read more here.
Keywords: notch signaling; neural stem; rnd3; genetic deletion ... See more keywords
Fibroblast-specific activation of Rnd3 protects against cardiac remodeling in diabetic cardiomyopathy via suppression of Notch and TGF-β signaling
Sign Up to like & getrecommendations! Published in 2022 at "Theranostics"
DOI: 10.7150/thno.77043
Abstract: Rationale: Extracellular matrix (ECM) remodeling, a key pathological feature in diabetic cardiomyopathy (DCM), is triggered by oxidative stress, inflammation, and various metabolic disorders in the heart. Cardiac fibroblasts (CFs) are the primary source of ECM… read more here.
Keywords: notch tgf; rnd3; fibroblast specific; tgf signaling ... See more keywords