RNF12 X-Linked Intellectual Disability Mutations Disrupt E3 Ligase Activity and Neural Differentiation
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DOI: 10.1016/j.celrep.2018.04.022
Abstract: Summary X-linked intellectual disability (XLID) is a heterogeneous syndrome affecting mainly males. Human genetics has identified >100 XLID genes, although the molecular and developmental mechanisms underpinning this disorder remain unclear. Here, we employ an embryonic… read more here.
Keywords: intellectual disability; activity; rnf12; linked intellectual ... See more keywords
Ring finger protein 12 activates AKT signalling to promote the progression of liver cancer by interacting with EGFR.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cellular and molecular medicine"
DOI: 10.1111/jcmm.17757
Abstract: Liver cancer is one of the most common solid tumours, and ranks as the third leading cause of cancer‐associated mortality around the world. This study has linked RNF12 to the pathogenesis of liver cancer. Based… read more here.
Keywords: liver cancer; rnf12; promote progression; cancer ... See more keywords